Abstract | BACKGROUND: STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: 12 renal registries providing individual RRT patient data to the European Renal Association-European Dialysis and Transplant Association (ERA- EDTA) Registry in 1993-2012 participated. PREDICTOR: OUTCOMES: Incidence, causes of death, and survival. MEASUREMENTS: ERA- EDTA primary renal disease codes. RESULTS: 2,511 patients with AAV (1,755, granulomatosis with polyangiitis; 756, microscopic polyangiitis) were identified, representing an incidence of 1.05 per million population (pmp) for granulomatosis with polyangiitis (predominating in Northern Europe) and 0.45 pmp for microscopic polyangiitis (prevailing in Southern Europe). Kidney transplantation was performed in 558 (22.2%) patients with vasculitis. The 10-year probability for survival on RRT after day 91 was 32.5% (95% CI, 29.9%-35.1%) in patients with vasculitis. Survival on RRT after day 91 did not differ between AAV and matched nondiabetes patients. Patient and transplant survival after kidney transplantation, adjusted for time period and country, was better in AAV than in matched nondiabetes patients (HRs of 0.81 [95% CI, 0.67-0.99] and 0.82 [95% CI, 0.69-0.96], respectively). LIMITATIONS: No data for extrarenal manifestations, treatment, and relapses. CONCLUSIONS:
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Authors | Zdenka Hruskova, Vianda S Stel, David Jayne, Knut Aasarød, Johan De Meester, Agneta Ekstrand, Kathrin Eller, James G Heaf, Andries Hoitsma, Carmen Martos Jimenéz, Pietro Ravani, Christoph Wanner, Vladimir Tesar, Kitty J Jager |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 66
Issue 4
Pg. 613-20
(Oct 2015)
ISSN: 1523-6838 [Electronic] United States |
PMID | 25975963
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Case-Control Studies
- Cause of Death
- Disease Progression
- Disease-Free Survival
- Europe
- Female
- Granulomatosis with Polyangiitis
(diagnosis, mortality, therapy)
- Humans
- Kaplan-Meier Estimate
- Kidney Failure, Chronic
(diagnosis, mortality, therapy)
- Kidney Function Tests
- Kidney Transplantation
(methods, mortality)
- Male
- Microscopic Polyangiitis
(diagnosis, mortality, therapy)
- Middle Aged
- Prognosis
- Proportional Hazards Models
- Registries
- Renal Dialysis
(methods, mortality)
- Severity of Illness Index
- Societies, Medical
- Survival Rate
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