Improvement of peripheral circulation by low density lipoprotein adsorption.

Abstract

Low density lipoprotein (LDL) was removed by repeated extracorporeal adsorption with a dextran sulphate cellulose column in 5 patients with clinical signs of poor peripheral circulation. The LDL apheresis was continued for 2 to 10 months, and symptoms such as cold or "heavy" legs, or intermittent claudication rapidly improved early in the treatment course in all 5 patients. Clearing of mentation occurred in 3, and recovery of kidney function was seen in 1 patient. These improvements occurred concomitant with a reduction in LDL level.

• Authors: T Agishi, Y Kitano, T Suzuki, A Miura, J Murakami, H Minagawa, K Ban
• Journal: ASAIO transactions (ASAIO Trans) 1989 Jul-Sep Vol. 35 Issue 3 Pg. 349-51 ISSN: 0889-7190 [Print] United States
• PMID: 2597479 (Publication Type: Journal Article)

Chemical References

• Cholesterol, LDL
• Lipoproteins, LDL

Topics

• Aged
• Aged, 80 and over
• Arteriosclerosis Obliterans (blood, therapy)
• Blood Component Removal
• Cholesterol, LDL (blood)
• Humans
• Intermittent Claudication (blood, therapy)
• Ischemia (blood, therapy)
• Leg (blood supply)
• Lipoproteins, LDL (blood)
• Male
• Middle Aged