Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation.

Abstract	Increased flux through the 5-HT pathway during hyperammonemia was indicated by a significant positive correlation between Gln concentration and the ratio of 5-HIAA to 5-HT in the brain of spf mice taken after microwave irradiation to prevent postmortem changes in metabolites. There were no significant changes in the catecholamine pathway in the brain during hyperammonemia despite the increases in Try and Phe.
Authors	I Inoue, T Shimizu, T Saheki, T Noda, T Fukuda
Journal	Biochemical medicine and metabolic biology (Biochem Med Metab Biol) Vol. 42 Issue 3 Pg. 232-9 (Dec 1989) ISSN: 0885-4505 [Print] United States
PMID	2597437 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Catecholamines Tissue Extracts Serotonin Ammonia
Topics	Ammonia (blood) Animals Brain (physiology) Brain Chemistry Catecholamines (metabolism) Mice Microwaves Ornithine Carbamoyltransferase Deficiency Disease Serotonin (metabolism) Specimen Handling Tissue Extracts (analysis)

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