Targeting gallbladder cancer: hyaluronan sensitizes cancer cells to chemo-therapeutics.

Abstract

Gallbladder cancer is the most common biliary tract malignancy and the fifth most common gastrointestinal malignancy. Chemo-resistance is the most remarkable characteristic of gallbladder cancer. The relatively dense extracellular space in tumor is the main barrier to nanotherapeutics' anticancer efficacy. Hyaluronan (HA) was shown in our previous study to significantly improve the myxoma virus distribution via promoting the MMP-9 production, which degrades collagen IV. We demonstrated that HA increased the chemo-sensitivity of gallbladder cancer cells both in vitro and in vivo. The in vivo chemo-sensitization effect of HA could partially be due to the penetration-promoting effect of HA via degrading collagen IV.

• Authors: Mingzhe Ma, Mingzhe Weng, Mingdi Zhang, Yiyu Qin, Wei Gong, Zhiwei Quan
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 2 Pg. 1822-5 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 25973074 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Hyaluronic Acid
• Paclitaxel

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Dose-Response Relationship, Drug
• Female
• Gallbladder Neoplasms (drug therapy, pathology)
• Humans
• Hyaluronic Acid (pharmacology)
• Mice, Nude
• Paclitaxel (pharmacology)
• Time Factors
• Tumor Burden (drug effects)
• Xenograft Model Antitumor Assays