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Effect of Causative Tooth Extraction on Clinical and Biological Parameters of Odontogenic Infection: A Prospective Clinical Trial.

AbstractPURPOSE:
To prospectively compare changes of body temperature, white blood cell count, fibrinogen, and C-reactive protein between odontogenic infections in which the responsible tooth was removed and odontogenic infections in which the treatment included no extraction.
MATERIALS AND METHODS:
The sample was composed of patients admitted to the authors' maxillofacial unit for odontogenic infection from 2010 through 2013. One hundred seventy-nine patients were categorized into an extraction or a non-extraction group based on whether the causative tooth was non-restorable or restorable, respectively. Non-restorable teeth were extracted at admission of the patient. Otherwise, the treatment protocol, including incision of the involved space in conjunction with intravenous antibiotics, was the same for the 2 groups. The parameters were measured and recorded at admission and 2 days later. Data records were statistically analyzed by comparing the change of the parameters studied between the extraction and non-extraction groups. P values less than .05 were regarded as statistically significant.
RESULTS:
One hundred seventy-nine patients fulfilled the inclusion criteria and were enrolled in the study. The mean age of the patients was 39.1 years (minimum, 14 yr; maximum, 81 yr; standard deviation, 15.4 yr). One hundred nine patients (60.9%) were male, and 70 (39.1%) were female. Differences in the mean decrease of axillary temperature, white blood cell count, fibrinogven, and C-reactive protein between the 2 groups were 0.178, 2,300, 1.01, and 0.64, respectively. All these differences were statistically significant (P =.02, .001, .001, and .001, respectively). Also, the mean hospital stay in the extraction group was 1.05 days shorter than in the non-extraction group, with the difference being statistically significant (P = .006).
CONCLUSIONS:
In odontogenic maxillofacial infections, extraction of the causative tooth is associated with a faster clinical and biological resolution of the infection.
AuthorsDimosthenis Igoumenakis, Nikolaos-Nikitas Giannakopoulos, Eleni Parara, Constantinos Mourouzis, George Rallis
JournalJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 73 Issue 7 Pg. 1254-8 (Jul 2015) ISSN: 1531-5053 [Electronic] United States
PMID25971920 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
CopyrightCopyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Fibrinogen
  • C-Reactive Protein
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents (therapeutic use)
  • Body Temperature (physiology)
  • C-Reactive Protein (analysis)
  • Dental Caries (surgery)
  • Female
  • Fibrinogen (analysis)
  • Follow-Up Studies
  • Gram-Positive Bacterial Infections (drug therapy, surgery)
  • Humans
  • Length of Stay
  • Leukocyte Count
  • Male
  • Middle Aged
  • Pericoronitis (surgery)
  • Prospective Studies
  • Staphylococcal Infections (drug therapy, surgery)
  • Streptococcal Infections (drug therapy, surgery)
  • Tooth Diseases (drug therapy, microbiology, surgery)
  • Tooth Extraction
  • Tooth Fractures (surgery)
  • Tooth Mobility (surgery)
  • Tooth Root (injuries)
  • Young Adult

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