Interaction between Erythrocyte Phospholipid Fatty Acids Composition and Variants of Inflammation-Related Genes on Type 2 Diabetes.

Abstract

AIMS:

The present study aimed to investigate the interaction between erythrocyte phospholipid (PL) fatty acids and variants of inflammation-related genes in a Chinese population.

METHODS:

A total of 622 patients with type 2 diabetes mellitus (T2DM) and 293 healthy subjects were included. Determination of erythrocyte PL fatty acids composition and genotyping of single nucleotide polymorphisms were conducted by standard methods.

RESULTS:

A significant interaction of rs7305618 on HNFIA with C18:2n-6 and C20:4n-6 was observed: T allele carriers (TT+CT) had a higher risk of T2DM than noncarriers only when they had a higher level of C18:2n-6 or C20:4n-6, and the odds ratios (ORs) were 2.59 (95% CI 1.58-4.24; p for interaction=0.005) and 2.49 (95% CI 1.47-4.24; p for interaction=0.021), respectively. A significant interaction of rs8078723 at the intergenic region between PSMD3 and CSF3 with C20:5n-3 was observed: C allele carriers (CC+CT) had a lower risk of T2DM than noncarriers only when they had a higher level of C20:5n-3, and the OR was 0.44 (95% CI 0.26-0.73; p for interaction=0.014).

CONCLUSIONS:

rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition.

• Authors: Kelei Li, Tao Huang, Ju-Sheng Zheng, Jianqin Sun, Yanqiu Chen, Hua Xie, Danfeng Xu, Jianbo Wan, Duo Li
• Journal: Journal of nutrigenetics and nutrigenomics (J Nutrigenet Nutrigenomics) Vol. 7 Issue 4-6 Pg. 252-63 ( 2014) ISSN: 1661-6758 [Electronic] Switzerland
• PMID: 25969153 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• Fatty Acids
• HNF1A protein, human
• Hepatocyte Nuclear Factor 1-alpha
• Phospholipids
• Granulocyte Colony-Stimulating Factor
• Proteasome Endopeptidase Complex
• proteasome activator PA700 subunit p58, human

Topics

• Adult
• Aged
• Asian People (genetics)
• Case-Control Studies
• China
• Diabetes Mellitus, Type 2 (blood, genetics)
• Erythrocytes (metabolism)
• Fatty Acids (blood)
• Female
• Genotype
• Granulocyte Colony-Stimulating Factor (genetics)
• Hepatocyte Nuclear Factor 1-alpha (genetics)
• Humans
• Male
• Middle Aged
• Nutrigenomics
• Phospholipids (blood)
• Polymorphism, Single Nucleotide
• Proteasome Endopeptidase Complex (genetics)
• Risk Factors