Residential radon and lung cancer characteristics in never smokers.

Abstract

PURPOSE:

The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis.

MATERIALS AND METHODS:

We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements.

RESULTS:

Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases.

CONCLUSIONS:

Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.

• Authors: María Torres-Durán, Alberto Ruano-Ravina, Isaura Parente-Lamelas, Virginia Leiro-Fernández, José Abal-Arca, Carmen Montero-Martínez, Carolina Pena-Álvarez, Olalla Castro-Añón, Antonio Golpe-Gómez, Cristina Martínez, Rosirys Guzmán-Taveras, María José Mejuto-Martí, Mariano Provencio, Alberto Fernández-Villar, Juan Miguel Barros-Dios
• Journal: International journal of radiation biology (Int J Radiat Biol) Vol. 91 Issue 8 Pg. 605-10 (Aug 2015) ISSN: 1362-3095 [Electronic] England
• PMID: 25968558 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Radon

Topics

• Adult
• Age Distribution
• Aged
• Air Pollution, Indoor (statistics & numerical data)
• Air Pollution, Radioactive (statistics & numerical data)
• Case-Control Studies
• Female
• Housing (statistics & numerical data)
• Humans
• Lung Neoplasms (epidemiology, pathology)
• Male
• Middle Aged
• Neoplasms, Radiation-Induced (epidemiology, pathology)
• Radiation Exposure (statistics & numerical data)
• Radon (analysis)
• Risk Factors
• Sex Distribution
• Smoking (epidemiology)
• Spain (epidemiology)