HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Residential radon and lung cancer characteristics in never smokers.

AbstractPURPOSE:
The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis.
MATERIALS AND METHODS:
We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements.
RESULTS:
Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases.
CONCLUSIONS:
Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.
AuthorsMaría Torres-Durán, Alberto Ruano-Ravina, Isaura Parente-Lamelas, Virginia Leiro-Fernández, José Abal-Arca, Carmen Montero-Martínez, Carolina Pena-Álvarez, Olalla Castro-Añón, Antonio Golpe-Gómez, Cristina Martínez, Rosirys Guzmán-Taveras, María José Mejuto-Martí, Mariano Provencio, Alberto Fernández-Villar, Juan Miguel Barros-Dios
JournalInternational journal of radiation biology (Int J Radiat Biol) Vol. 91 Issue 8 Pg. 605-10 (Aug 2015) ISSN: 1362-3095 [Electronic] England
PMID25968558 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Radon
Topics
  • Adult
  • Age Distribution
  • Aged
  • Air Pollution, Indoor (statistics & numerical data)
  • Air Pollution, Radioactive (statistics & numerical data)
  • Case-Control Studies
  • Female
  • Housing (statistics & numerical data)
  • Humans
  • Lung Neoplasms (epidemiology, pathology)
  • Male
  • Middle Aged
  • Neoplasms, Radiation-Induced (epidemiology, pathology)
  • Radiation Exposure (statistics & numerical data)
  • Radon (analysis)
  • Risk Factors
  • Sex Distribution
  • Smoking (epidemiology)
  • Spain (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: