Near-infrared-absorbing gold nanopopcorns with iron oxide cluster core for magnetically amplified photothermal and photodynamic cancer therapy.

Abstract

We present the synthesis and application of a new type of dual magnetic and plasmonic nanostructures for magnetic-field-guided drug delivery and combined photothermal and photodynamic cancer therapy. Near-infrared-absorbing gold nanopopcorns containing a self-assembled iron oxide cluster core were prepared via a seed-mediated growth method. The hybrid nanostructures are superparamagnetic and show great photothermal conversion efficiency (η=61%) under near-infrared irradiation. Compact and stable nanocomplexes for photothermal-photodynamic therapy were formed by coating the nanoparticles with near-infrared-absorbing photosensitizer silicon 2,3-naphthalocyannie dihydroxide and stabilization with poly(ethylene glycol) linked with 11-mercaptoundecanoic acid. The nanocomplex showed enhanced release and cellular uptake of the photosensitizer with the use of a gradient magnetic field. In vitro studies using two different cell lines showed that the dual mode photothermal and photodynamic therapy with the assistance of magnetic-field-guided drug delivery dramatically improved the therapeutic efficacy of cancer cells as compared to the combination treatment without using a magnetic field and the two treatments alone. The "three-in-one" nanocomplex has the potential to carry therapeutic agents deep into a tumor through magnetic manipulation and to completely eradicate tumors by subsequent photothermal and photodynamic therapies without systemic toxicity.

• Authors: Saheel Bhana, Gan Lin, Lijia Wang, Hunter Starring, Sanjay R Mishra, Gang Liu, Xiaohua Huang
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 7 Issue 21 Pg. 11637-47 (Jun 03 2015) ISSN: 1944-8252 [Electronic] United States
• PMID: 25965727 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Magnetite Nanoparticles
• Nanocapsules
• Photosensitizing Agents
• Gold

Topics

• Absorption, Radiation
• Breast Neoplasms (drug therapy, pathology)
• Cell Line, Tumor
• Cell Survival (drug effects, radiation effects)
• Gold (chemistry, radiation effects, therapeutic use)
• Humans
• Hyperthermia, Induced (methods)
• Infrared Rays (therapeutic use)
• Magnetite Nanoparticles (chemistry, ultrastructure)
• Nanocapsules (chemistry, ultrastructure)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage, chemistry)
• Phototherapy (methods)
• Treatment Outcome