Mn2+-doped prussian blue nanocubes for bimodal imaging and photothermal therapy with enhanced performance.

Abstract

Prussian blue (PB) as a clinically adapted agent recently has drawn much attention in cancer theranostics for potential applications in magnetic resonance (MR) imaging as well as photothermal cancer treatment. In this work, we take a closer look at the imaging and therapy performance of PB agents once they are doped with Mn2+. It is found that Mn2+-doped PB nanocubes exhibit increased longitudinal relaxivity along with enhanced optical absorption red-shifted to the near-infrared (NIR) region. Those properties make PB:Mn nanocubes with appropriate surface coatings rather attractive agents for biomedical imaging and cancer therapy, which have been successfully demonstrated in our in vivo experiments for effectively tumor ablation.

• Authors: Wenwen Zhu, Kai Liu, Xiaoqi Sun, Xin Wang, Yonggang Li, Liang Cheng, Zhuang Liu
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 7 Issue 21 Pg. 11575-82 (Jun 03 2015) ISSN: 1944-8252 [Electronic] United States
• PMID: 25965554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Ferrocyanides
• Nanocapsules
• Photosensitizing Agents
• Manganese
• ferric ferrocyanide

Topics

• Animals
• Cell Line, Tumor
• Contrast Media (chemistry)
• Ferrocyanides (chemistry, therapeutic use)
• Magnetic Resonance Imaging (methods)
• Manganese (chemistry)
• Metal Nanoparticles (chemistry, therapeutic use, ultrastructure)
• Mice
• Mice, Inbred BALB C
• Nanocapsules (administration & dosage, chemistry, ultrastructure)
• Neoplasms, Experimental (drug therapy, pathology)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage, chemistry)
• Theranostic Nanomedicine (methods)
• Treatment Outcome