Long-term outcome of HLA-haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion based on an FBCA conditioning regimen for hematologic malignancies.

Abstract

Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is an alternative for patients who need a transplant without having conventional donors. One hundred and five consecutive patients with hematologic malignancies who underwent G-CSF-primed peripheral blood haplo-HSCT without in vitro T-cell depletion in our single center were reported in this study. Patients were categorized into the intermediate-risk group (n=28) or high-risk group (n=77) according to the risk stratification. The conditioning regimen included fludarabine, busulfan, cyclophosphamide and anti-lymphocyte globulin. The cumulative incidence of grades II-IV acute GvHD (aGvHD) on day +100 was 21.9%, and that of grades III-IV aGvHD was 14.3%. The 2-year cumulative incidence of total chronic GvHD (cGvHD) was 24.1%, and that of extensive cGvHD was 5.6% in 83 eligible patients. The 3-year cumulative incidence rates of relapse and no relapse mortality were 21.9% and 30.5%, respectively. After a median follow-up of 35 months, the 3-year probabilities of overall and disease-free survival for the intermediate-risk and high-risk groups were 63.2% and 39.8% and 61.2% and 32.2%, respectively. In multivariate analysis, the outcome of survival (overall survival and disease-free survival) was associated with the risk stratification, disease status at transplant and dose of infused mononuclear cells. Our results suggest that unmanipulated peripheral blood stem cell allograft performed with fludarabine, busulfan, cyclophosphamide and anti-lymphocyte globulin conditioning regimen is feasible.

• Authors: X Lin, Z G Lu, C Y Song, Y X Huang, K Y Guo, L Deng, S F Tu, Y Z He, J H Xu, H Long, B Y Wu
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 50 Issue 8 Pg. 1092-7 (Aug 2015) ISSN: 1476-5365 [Electronic] England
• PMID: 25961770 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclophosphamide
• Vidarabine
• Busulfan
• fludarabine

Topics

• Adolescent
• Adult
• Allografts
• Busulfan (administration & dosage)
• Child
• Cyclophosphamide (administration & dosage)
• Disease-Free Survival
• Female
• Follow-Up Studies
• Hematologic Neoplasms (mortality, therapy)
• Hematopoietic Stem Cell Transplantation
• Histocompatibility Testing
• Humans
• Lymphocyte Depletion (methods)
• Male
• Middle Aged
• Survival Rate
• T-Lymphocytes
• Transplantation Conditioning (methods)
• Vidarabine (administration & dosage, analogs & derivatives)