Giant malignant insulinoma.

Abstract

Insulinomas are the most common pancreatic neuroendocrine tumors. Most insulinomas are benign, small, intrapancreatic solid tumors and only large tumors have a tendency for malignancy. Most patients present with symptoms of hypoglycemia that are relieved with the administration of glucose. We herein present the case of a 75-year-old woman who presented with an acute hypoglycemic episode. Subsequent laboratory and radiological studies established the diagnosis of a 17-cm malignant insulinoma, with local invasion to the left kidney, lymph node metastasis, and hepatic metastases. Patient symptoms, diagnostic and imaging work-up and surgical management of both the primary and the metastatic disease are reviewed.

• Authors: Dimitrios Karavias, Ioannis Habeos, Ioannis Maroulis, Christina Kalogeropoulou, Athanasios Tsamandas, Ioannis Chaveles, Dionissios Karavias
• Journal: Annals of surgical treatment and research (Ann Surg Treat Res) Vol. 88 Issue 5 Pg. 289-93 (May 2015) ISSN: 2288-6575 [Print] Korea (South)
• PMID: 25960993 (Publication Type: Case Reports)