Correlations between drug resistance of Beijing/W lineage clinical isolates of Mycobacterium tuberculosis and sublineages: a 2009-2013 prospective study in Xinjiang province, China.

Abstract

BACKGROUND:

The prevalence of drug-resistant tuberculosis (TB) in Xinjiang is higher than in other regions of China, and Beijing/W lineage Mycobacterium tuberculosis (MTB) is the dominant strain of MTB in Xinjiang. However, information on multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, particularly the correlation between MDR and the Beijing/W lineage and the correlation between drug resistance and the Beijing/W sublineage strains, is limited.

MATERIAL/METHODS:

We conducted a prospective study to describe the prevalence of MDR/XDR TB, Beijing/W lineage and sublineage strains in Xinjiang in China from 2009 to 2013. All MTB underwent drug susceptibility testing to the first- and second-line anti-tuberculosis drugs. The Beijing/W lineages and sublineages were detected by large-sequence polymorphisms with polymerase chain reaction.

RESULTS:

A total of 410 clinical isolates were identified. The overall percentage of MDR and XDR cases in Xinjiang was 13.2% (54/410) and 13.0% (7/54), respectively. Overall, 9.8% (14/143) of the Beijing lineage MTB were MDR patients, and 15.6% (40/257) of the Non-Beijing lineage MTB were MDR patients. In the 143 Beijing MTB lineages, 11.2% isolates were in sublineage 105, 15.4% isolates were in sublineage 207, 69.2% isolates were in sublineage 181, and 4.2% isolates were in sublineage 150. None of the isolates were detected in sublineage 142. Significant differences between the Beijing/W and non-Beijing/W strains were observed regarding INH and EMB resistance, respectively.

CONCLUSIONS:

The prevalence of the MDR TB in Xinjiang remains high and imposes challenges for TB control. Four Beijing/W sublineage isolates were observed in Xinjiang. There was no correlation between MDR and the Beijing/W lineage and no correlation between drug resistance and the Beijing/W sublineage strains. Surveillance of the clinical isolates of MTB is recommended to strengthen the identification of MDR/XDR TB and sublineages of the Beijing/W strains.

• Authors: Xian-hua Wang, Ai-guo Ma, Xiu-xia Han, Xiao-ming Gu, Li-ping Fu, Peng-gang Li, Fen-yu Li, Qiu-zhen Wang, Hui Liang, Abudu Katar, Li-jie Wang
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 21 Pg. 1313-8 (May 07 2015) ISSN: 1643-3750 [Electronic] United States
• PMID: 25950148 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antitubercular Agents
• DNA, Bacterial

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Antitubercular Agents (classification, pharmacology, therapeutic use)
• Child
• Child, Preschool
• China (epidemiology)
• DNA, Bacterial (genetics)
• Drug Resistance, Multiple, Bacterial (genetics)
• Extensively Drug-Resistant Tuberculosis (epidemiology, microbiology)
• Female
• Genes, Bacterial
• Humans
• Male
• Middle Aged
• Mycobacterium tuberculosis (classification, drug effects, genetics)
• Prevalence
• Prospective Studies
• Species Specificity
• Tuberculosis, Multidrug-Resistant (epidemiology, microbiology)
• Young Adult