[Zoledronic acid (zoledronate) in children with osteogenesis imperfecta].

Abstract

INTRODUCTION:

Zoledronic acid or zo/edronate is a potent bisphosphonate that recently has been used in children with osteoporosis and osteogenesis imperfecta (01), so it could be an option in the treatment of children with this terrible disease that virtually condemns them to a life of pain and prostration. The aim of this study was to evaluate the clinical and biochemical conditions of pediatric patients with 01 before and after treatment with zo /edronate.

RESULTS:

We included 14 patients, median age six years (6 months to 14 years), eight (57.1 %) males and six (42 .9%) females, weight 19 kg (5.8-45 kg). According to the type of 01, six (42.9%) were type I, six (42.9%) type Ill, and two (14.2%) type IV The functional score (Bleck) previous to treatment was 4 (1-9) and 6 (2-9) after treatment (p = 0.001). Pain intensity prior to zo/edronate was 2 (1-9) and 0 (0-2) after (p = 0.008). Previous fractures five (1-15) and post-treatment one (0-2) (p = 0.001 ). There were no significant differences in calcium, phosphorus, alkaline phosphatase, and parathyroid hormone.

CONCLUSIONS:

Zoledronic acid decreases the number of bone fractures and pain in children with osteogenesis imperfect and improves functional status. The most common side effects were fever and bone pain within five days after the infusion,which disappear paracetamol. No adverse long-term effects such as hypocalcemia or hypoparathyroidism were reported.

• Authors: Luz María Sánchez-Sánchez, Alfredo Uriel Cabrera-Pedroza, Gerardo Palacios-Saucedo, Beatriz de la Fuente-Cortez
• Journal: Gaceta medica de Mexico (Gac Med Mex) 2015 Mar-Apr Vol. 151 Issue 2 Pg. 164-8 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: Ácido zoledrónico (zolendronato) en niños con osteogénesis imperfecta.
• PMID: 25946526 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Bone Density Conservation Agents
• Diphosphonates
• Imidazoles
• Zoledronic Acid

Topics

• Adolescent
• Bone Density Conservation Agents (therapeutic use)
• Child
• Child, Preschool
• Diphosphonates (therapeutic use)
• Female
• Humans
• Imidazoles (therapeutic use)
• Infant
• Male
• Osteogenesis Imperfecta (diagnosis, drug therapy)
• Zoledronic Acid