Abstract | CONTEXT: Pistacia lentiscus L. (Anacardiaceae) is an evergreen shrub widely distributed throughout the Mediterranean region. Pistacia lentiscus oil (PLo) was particularly known in North African traditional medicine. Thus, people of these regions have used it externally to treat sore throats, burns and wounds, as well as they employed it internally for respiratory allergies. PLo is rich in essential fatty acids, vitamin E and polyphenols. As a very active site of metabolism, liver is reported to be susceptible to arsenic (As) intoxication. OBJECTIVE: The present study evaluates the protective effect of PLo against sodium arsenite-induced hepatic dysfunction and oxidative stress in experimental Wistar rats. MATERIALS AND METHODS: Twenty-eight rats were equally divided into four groups; the first served as a control, the remaining groups were respectively treated with PLo (3.3 mL/kg body weight), sodium arsenite (5.55 mg/kg body weight) and a combination of sodium arsenite and PLo. After 21 consecutive days, cellular functions were evaluated by hematological, biochemical and oxidative stress markers. RESULTS: CONCLUSION:
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Authors | Fahima Klibet, Amel Boumendjel, Mohamed Khiari, Abdelfattah El Feki, Cherif Abdennour, Mahfoud Messarah |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 54
Issue 2
Pg. 354-63
( 2016)
ISSN: 1744-5116 [Electronic] England |
PMID | 25946016
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Arsenites
- Biomarkers
- Plant Oils
- Sodium Compounds
- sodium arsenite
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Topics |
- Animals
- Antioxidants
(metabolism)
- Arsenites
(toxicity)
- Biomarkers
(blood)
- Body Weight
(drug effects)
- Chemical and Drug Induced Liver Injury
(blood, metabolism, prevention & control)
- Lipid Peroxidation
(drug effects)
- Liver
(drug effects, metabolism, pathology)
- Liver Function Tests
- Male
- Organ Size
(drug effects)
- Oxidative Stress
(drug effects)
- Pistacia
(chemistry)
- Plant Oils
(isolation & purification, therapeutic use)
- Rats, Wistar
- Sodium Compounds
(toxicity)
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