Kinetics and Immunodominance of Virus-Specific T Cell Responses During Hantaan Virus Infection.

Abstract

Immunodominant T cell responses are important for protection against virus challenge. However, studies screening for the immunodominant T cell responses and following their kinetics in acute Hantaan virus (HTNV) infection are very limited. Herein, the HTNV nucleocapsid protein-specific T cell responses were longitudinally screened in 15 patients with acute HTNV infection, eight of whom had a particularly severe hemorrhagic fever with renal syndrome (HFRS). An extremely impaired IFN-γ-producing T cell response was observed in patients with severe HFRS at the early stage of infection, especially to the immunodominant epitopes detected in the mild to moderate group, namely peptides N127-141, N139-153, N241-255, and N355-369. The initially insufficient T cell response to the immunodominant epitopes may play a role in influencing the severity of HTNV infection. These findings provide information that may aid the design of future vaccines against hantaviruses.

• Authors: Meiliang Wang, Jiuping Wang, Zhenhua Kang, Qiuling Zhao, Xiaohui Wang, Ling Hui
• Journal: Viral immunology (Viral Immunol) Vol. 28 Issue 5 Pg. 265-71 (Jun 2015) ISSN: 1557-8976 [Electronic] United States
• PMID: 25945718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Capsid Proteins
• Epitopes, T-Lymphocyte
• Immunodominant Epitopes
• Viral Core Proteins
• nucleocapsid protein, Hantaan virus
• Interferon-gamma

Topics

• Adult
• Aged
• CD8-Positive T-Lymphocytes (immunology)
• Capsid Proteins (immunology)
• Epitopes, T-Lymphocyte (immunology)
• Female
• Hantaan virus (immunology)
• Hantavirus Infections (immunology, virology)
• Hemorrhagic Fever with Renal Syndrome (immunology, virology)
• Humans
• Immunodominant Epitopes (immunology)
• Interferon-gamma (immunology)
• Male
• Middle Aged
• Viral Core Proteins (immunology)
• Young Adult