Activation of insulin-like growth factor 1 receptor in patients with non-small cell lung cancer.

Abstract

According to previous reports demonstrating the implication of insulin-like growth factor receptor (IGF-1R) signaling in non-small cell lung cancer (NSCLC), in this study, the potential prognostic values of IGF-1R expression/activation were analyzed. The expression and activation of IGF-1R were evaluated in two tissue microarray (TMA) sets from NSCLC patients (N = 352 for TMA I, and N = 353 for TMA II). Alterations in IGF-1R protein or mRNA expression in NSCLC patients were evaluated using publicly available data from The Cancer Genome Atlas (TCGA). We found that membranous and cytoplasmic IGF-1R expressions were significantly associated with squamous cell carcinoma (SCC) in both of the TMAs. Analysis of the TCGA data revealed increased mRNA levels in NSCLC patients, which was significantly associated with reductions in overall survival (OS) (median survival 26.51 vs. 47.77 months, P = 0.017) and disease-free survival (median survival 17.44 vs. 37.65 months, P = 0.045) only in NSCLC patients with adenocarcinoma (ADC). These data suggest that IGF-1R is activated in patients with NSCLC, particularly those with SCC. IGF-1R mRNA expression is a potential prognostic factor in patients with NSCLC, especially those with ADC. Further studies are warranted to investigate the prognostic value of IGF-1R in NSCLC patients.

• Authors: Jin-Soo Kim, Edward S Kim, Diane Liu, J Jack Lee, Carmen Behrens, Scott M Lippman, Waun Ki Hong, Ignacio I Wistuba, Euni Lee, Ho-Young Lee
• Journal: Oncotarget (Oncotarget) Vol. 6 Issue 18 Pg. 16746-56 (Jun 30 2015) ISSN: 1949-2553 [Electronic] United States
• PMID: 25944691 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Biomarkers, Tumor
• Receptor, IGF Type 1

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (genetics, metabolism)
• Carcinoma, Non-Small-Cell Lung (genetics, mortality, pathology)
• Carcinoma, Squamous Cell (genetics, pathology)
• Disease-Free Survival
• Enzyme Activation
• Female
• Humans
• Lung Neoplasms (genetics, mortality, pathology)
• Male
• Middle Aged
• Receptor, IGF Type 1 (genetics, metabolism)
• Tissue Array Analysis