Anesthesia and organic aciduria: is the use of lactated Ringer's solution absolutely contraindicated?

Abstract

BACKGROUND:

Organic acidurias (OAs) are rare inborn errors of metabolism that can present with various neurologic manifestations, propensity for acute metabolic decompensation with anion-gap metabolic acidosis, developmental delay, poor feeding, and failure to thrive.

OBJECTIVE:

In this case series, we outline the anesthetic management and perioperative outcomes of OA patients.

METHODS:

We reviewed demographic characteristics, comorbidities, and perioperative course of patients with four different OAs who underwent anesthetic care at our institution between January 1, 2000, and December 31, 2013.

RESULTS:

Eleven patients with OA underwent 19 anesthetic procedures, of which 13 were <2 h in duration and seven were outpatient procedures. One patient with methylmalonic acidemia developed metabolic acidosis during a 10-h procedure with substantial blood loss but lacked evidence that this acidosis could be attributed to his underlying metabolic disease. The patients who received hydration with lactated Ringer's solution and/or nitrous oxide anesthetic had a perioperative course free of metabolic complication. Two patients died within 30 days of surgery from causes likely to be unrelated to anesthetic exposure.

CONCLUSIONS:

Our patients with various forms of metabolically compensated OAs tolerated anesthetics for surgical procedures without metabolic decompensation, even when lactated Ringer's solution was used for hydration. Measures to prevent protein catabolism and intraoperative events that may precipitate metabolic acidosis, in addition to close monitoring of acid-base status during more extensive procedures, must be part of perioperative treatment of these patients.

• Authors: Katerina Ruzkova, Toby N Weingarten, Kelly J Larson, Robert J Friedhoff, Dimitar K Gavrilov, Juraj Sprung
• Journal: Paediatric anaesthesia (Paediatr Anaesth) Vol. 25 Issue 8 Pg. 807-817 (Aug 2015) ISSN: 1460-9592 [Electronic] France
• PMID: 25943188 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons Ltd.

Chemical References

• Isotonic Solutions
• Ringer's Lactate

Topics

• Acidosis (complications)
• Adolescent
• Adult
• Amino Acid Metabolism, Inborn Errors (complications, surgery)
• Anesthesia (methods)
• Child
• Child, Preschool
• Female
• Humans
• Isotonic Solutions (administration & dosage)
• Male
• Ringer's Lactate
• Young Adult