Effect of toothpaste with nano-sized trimetaphosphate on dental caries: In situ study.

Abstract

OBJECTIVES:

This in situ study was to evaluate the remineralizing effect of a fluoride toothpaste supplemented with nano-sized sodium trimetaphosphate (TMP).

METHODS:

This blind and cross-over study was performed in 4 phases of 3 days each. Twelve subjects used palatal appliances containing four bovine enamel blocks with artificial caries lesions. Volunteers were randomly assigned into the following treatment groups: Placebo (without F and TMP); 1100 ppm F (1100), 1100 supplemented with 3% micrometric TMP (1100 TMP) and with nano-sized TMP (1100 TMPnano). Volunteers were instructed to brush their natural teeth with the palatal appliances in the mouth during 1min (3 times/day), so that blocks were treated with natural slurries of toothpastes. After each phase, the percentage of surface hardness recovery (%SHR), integrated mineral recovery (IMR) and integrated differential mineral area profile (ΔIMR) in enamel lesions were calculated. F in enamel was also determined. Data were analyzed by ANOVA and Student-Newman-Keuls test.

RESULTS:

Enamel surface became 20% harder when treated with 1100 TMPnano in comparison with 1100 (p<0.001). 1100 TMPnano showed remineralizing capacity (IMR; ΔIMR) 66% higher when compared with 1100 TMP (p<0.001). Enamel F uptake in the 1100 TMPnano group was 2-fold higher when compared to its counterpart without TMP (p<0.001).

CONCLUSION:

The addition of 3% TMPnano to a conventional toothpaste was able to promote an additional remineralizing effect of artificial caries lesions.

CLINICAL SIGNIFICANCE:

Toothpaste containing 1100 ppm F associated with TMPnano showed a potential of higher remineralization to 1100 ppm F and 1100 ppm F micrometric TMP.

• Authors: Marcelle Danelon, Juliano Pelim Pessan, Francisco Nunes Souza Neto, Emerson Rodrigues de Camargo, Alberto Carlos Botazzo Delbem
• Journal: Journal of dentistry (J Dent) Vol. 43 Issue 7 Pg. 806-13 (Jul 2015) ISSN: 1879-176X [Electronic] England
• PMID: 25936338 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Fluorides, Topical
• Polyphosphates
• Toothpastes
• trimetaphosphoric acid

Topics

• Adult
• Animals
• Cattle
• Cross-Over Studies
• Dental Caries (drug therapy)
• Female
• Fluorides, Topical (administration & dosage)
• Hardness (drug effects)
• Humans
• Male
• Nanoparticles (administration & dosage, chemistry)
• Polyphosphates (administration & dosage, pharmacology, therapeutic use)
• Tooth Remineralization
• Toothpastes (chemistry, therapeutic use)
• Young Adult