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Study on the use of toltrazuril to eliminate Neospora caninum in congenitally infected lambs born from experimentally infected ewes.

Abstract
To determine if toltrazuril was effective in eliminating Neospora caninum infection from congenitally infected lambs. Twenty-eight ewes were allocated to 3 groups where animals in Groups A and B were inoculated with 1 × 10(7)N. caninum tachyzoites on Day 120 of gestation and Group C was maintained as a negative control group. Lambs born from ewes in Group A were treated with toltrazuril (20mg/kg) on Days 0, 7, 14 and 21 after birth. Lambs in Groups B and C were untreated. All lambs in Groups A and B were seropositive at 12 weeks of age. At 12 weeks of age, no differences between lambs in Group A and Group B were observed in serological results (ELISA and western blot), presence of N. caninum-related brain histopathological lesions or the number of organisms detected by qPCR. Group C remained negative for serology, detection of N. caninum DNA as well as histopathology throughout the study. Results indicate that N. caninum congenitally-infected lambs had a continuing infection with N. caninum despite being treated with toltrazuril.
AuthorsS S Syed-Hussain, L Howe, W E Pomroy, D M West, M Hardcastle, N B Williamson
JournalVeterinary parasitology (Vet Parasitol) Vol. 210 Issue 3-4 Pg. 141-4 (Jun 15 2015) ISSN: 1873-2550 [Electronic] Netherlands
PMID25935293 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Triazines
  • toltrazuril
Topics
  • Animals
  • Animals, Newborn
  • Coccidiosis (drug therapy, transmission, veterinary)
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay (veterinary)
  • Female
  • Infectious Disease Transmission, Vertical (prevention & control, veterinary)
  • Neospora (drug effects, genetics, immunology, isolation & purification)
  • Polymerase Chain Reaction (veterinary)
  • Sheep
  • Sheep Diseases (drug therapy, transmission)
  • Triazines (therapeutic use)

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