Abstract |
To determine if toltrazuril was effective in eliminating Neospora caninum infection from congenitally infected lambs. Twenty-eight ewes were allocated to 3 groups where animals in Groups A and B were inoculated with 1 × 10(7)N. caninum tachyzoites on Day 120 of gestation and Group C was maintained as a negative control group. Lambs born from ewes in Group A were treated with toltrazuril (20mg/kg) on Days 0, 7, 14 and 21 after birth. Lambs in Groups B and C were untreated. All lambs in Groups A and B were seropositive at 12 weeks of age. At 12 weeks of age, no differences between lambs in Group A and Group B were observed in serological results (ELISA and western blot), presence of N. caninum-related brain histopathological lesions or the number of organisms detected by qPCR. Group C remained negative for serology, detection of N. caninum DNA as well as histopathology throughout the study. Results indicate that N. caninum congenitally-infected lambs had a continuing infection with N. caninum despite being treated with toltrazuril.
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Authors | S S Syed-Hussain, L Howe, W E Pomroy, D M West, M Hardcastle, N B Williamson |
Journal | Veterinary parasitology
(Vet Parasitol)
Vol. 210
Issue 3-4
Pg. 141-4
(Jun 15 2015)
ISSN: 1873-2550 [Electronic] Netherlands |
PMID | 25935293
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Animals
- Animals, Newborn
- Coccidiosis
(drug therapy, transmission, veterinary)
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
(veterinary)
- Female
- Infectious Disease Transmission, Vertical
(prevention & control, veterinary)
- Neospora
(drug effects, genetics, immunology, isolation & purification)
- Polymerase Chain Reaction
(veterinary)
- Sheep
- Sheep Diseases
(drug therapy, transmission)
- Triazines
(therapeutic use)
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