Abstract | BACKGROUND: METHODS:
Tremor, locomotor activity and focused stereotypy were measured objectively using force plate actimeters. Tremor was analyzed using a Fourier transform to generate power spectra for rhythmic behavior. RESULTS: The tremor induced by harmaline administered at a dose of 15 mg/kg ip was associated with an increase in power in the 9-15 Hz band (AP2) and in the tremor index, calculated as a difference between AP2 and power in the 0-8 Hz band (AP1). Propranolol injected at a dose of 20mg/kg ip reversed both of these effects of harmaline. Apomorphine administered at the doses of 0.5 and 1mg/kg sc further enhanced AP2 and at the lower dose also the tremor index elevated by harmaline. This increase in AP2 was stronger than enhancement of locomotor activity induced by apomorphine in the harmaline-treated animals. CONCLUSIONS:
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Authors | Krystyna Ossowska, Urszula Głowacka, Barbara Kosmowska, Jadwiga Wardas |
Journal | Pharmacological reports : PR
(Pharmacol Rep)
Vol. 67
Issue 3
Pg. 435-41
(Jun 2015)
ISSN: 2299-5684 [Electronic] Switzerland |
PMID | 25933950
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. |
Chemical References |
- Central Nervous System Stimulants
- Dopamine Agonists
- Harmaline
- Apomorphine
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Topics |
- Animals
- Apomorphine
(administration & dosage, toxicity)
- Central Nervous System Stimulants
(administration & dosage, toxicity)
- Dopamine Agonists
(administration & dosage, toxicity)
- Drug Synergism
- Harmaline
(administration & dosage, toxicity)
- Male
- Rats
- Rats, Wistar
- Tremor
(chemically induced, pathology)
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