Abstract | BACKGROUND: CASE PRESENTATION: A 30 year old Pakistani woman, presented with a small nodule in the floor of the mouth. An excisional biopsy revealed CD20, CD3, and CD117 negative and CD138, CD79a, CD56, MUM1/IFR4 and CD30 positive lesion with Ki-67 of 60% with cells which were plasmablastic in appearance. The morphological and immunohistochemistry features were consistent with plasmablastic lymphoma. The staging scans did not reveal any lymphadenopathy and the bone marrow biopsy and human immunodeficiency virus test were both negative. After treatment with four courses of CHOP and later radiation to the floor of the mouth, her disease was in complete remission. Two months later, she presented with velvety red lesions in both breasts and its trucut biopsy was consistent with plasmablastic lymphoma. Her CT scans revealed multiple nodules involving both breasts with no lymphadenopathy. The bone marrow was now positive for disease. Her disease continued to progress despite second and third line chemotherapy with DHAP ( dexamethasone, cisplatin and cytarabine) and ICE ( ifosfamide, carboplatin and etoposide) respectively. Her last CT scans revealed progressive disease with new lung lesions. The patient decided to opt for best supportive care. CONCLUSION: To our knowledge this is the second report of plasmablastic lymphoma involving the breast. The patient who was human immunodeficiency virus negative and immune competent had progressive disease despite three lines of chemotherapies with an overall survival (to date) of 15 months.
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Authors | Zarka Samoon, Romana Idrees, Nehal Masood, Tayyaba Zehra Ansari |
Journal | BMC research notes
(BMC Res Notes)
Vol. 8
Pg. 180
(May 02 2015)
ISSN: 1756-0500 [Electronic] England |
PMID | 25933603
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Biopsy
- Breast
(pathology)
- Breast Neoplasms
(pathology)
- CD79 Antigens
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Mouth
(pathology)
- Mouth Neoplasms
(pathology)
- Neoplasm Recurrence, Local
(pathology)
- Plasmablastic Lymphoma
(pathology)
- Syndecan-1
(metabolism)
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