Indications for superselective intra-arterial cisplatin infusion and concomitant radiotherapy in cases of hypopharyngeal cancer.

Abstract

OBJECTIVE:

We retrospectively assessed the indications for superselective intra-arterial infusion of cisplatin with concomitant radiotherapy (RADPLAT) in patients with hypopharyngeal cancer (HPC).

METHODS:

Between April 2000 and March 2013, 41 previously untreated patients received superselective intra-arterial infusion of cisplatin (100-120mg/m(2) per week) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional radiotherapy (65-70Gy).

RESULTS:

During the median follow-up period of 5.5 years, a statistically significant difference in the 5-year overall survival was noted between patients with N0-1 (n=14) and N2b-3 disease (n=27). One-half of deaths were observed to be the result of distant metastasis. The 5-year local control and overall survival were significantly better in patients with unilateral than in those with bilateral primary tumors. All the patients with T4b disease (n=3) died of disease within 2 years.

CONCLUSION:

Indications for RADPLAT in patients with HPC were defined as patients with unilateral tumors staged as T3-4a and N0-1.

• Authors: Jun Furusawa, Akihiro Homma, Rikiya Onimaru, Tomohiro Sakashita, Daisuke Yoshida, Hiromitsu Hatakeyama, Takatsugu Mizumachi, Satoshi Kano, Kazuhiko Tsuchiya, Koichi Yasuda, Hiroki Shirato, Satoshi Fukuda
• Journal: Auris, nasus, larynx (Auris Nasus Larynx) Vol. 42 Issue 6 Pg. 443-8 (Dec 2015) ISSN: 1879-1476 [Electronic] Netherlands
• PMID: 25933585 (Publication Type: Clinical Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Aged
• Antineoplastic Agents (therapeutic use)
• Carcinoma, Squamous Cell (pathology, therapy)
• Chemoradiotherapy (methods)
• Cisplatin (therapeutic use)
• Cohort Studies
• Female
• Head and Neck Neoplasms (pathology, therapy)
• Humans
• Hypopharyngeal Neoplasms (pathology, therapy)
• Infusions, Intra-Arterial
• Male
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Squamous Cell Carcinoma of Head and Neck
• Survival Rate