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Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.

Abstract
Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.
AuthorsMiguel A Barbancho, Marcelo L Berthier, Patricia Navas-Sánchez, Guadalupe Dávila, Cristina Green-Heredia, José M García-Alberca, Rafael Ruiz-Cruces, Manuel V López-González, Marc S Dawid-Milner, Friedemann Pulvermüller, J Pablo Lara
JournalBrain and language (Brain Lang) 2015 Jun-Jul Vol. 145-146 Pg. 1-10 ISSN: 1090-2155 [Electronic] Netherlands
PMID25932618 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Memantine
Topics
  • Adult
  • Aged
  • Aphasia (etiology, physiopathology, therapy)
  • Brain (drug effects, physiology)
  • Double-Blind Method
  • Evoked Potentials (drug effects, physiology)
  • Female
  • Functional Laterality (drug effects, physiology)
  • Humans
  • Language Therapy (methods)
  • Male
  • Memantine (pharmacology, therapeutic use)
  • Middle Aged
  • Photic Stimulation (methods)
  • Reading
  • Stroke (complications, physiopathology, therapy)

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