Abstract |
Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post- stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.
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Authors | Miguel A Barbancho, Marcelo L Berthier, Patricia Navas-Sánchez, Guadalupe Dávila, Cristina Green-Heredia, José M García-Alberca, Rafael Ruiz-Cruces, Manuel V López-González, Marc S Dawid-Milner, Friedemann Pulvermüller, J Pablo Lara |
Journal | Brain and language
(Brain Lang)
2015 Jun-Jul
Vol. 145-146
Pg. 1-10
ISSN: 1090-2155 [Electronic] Netherlands |
PMID | 25932618
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aphasia
(etiology, physiopathology, therapy)
- Brain
(drug effects, physiology)
- Double-Blind Method
- Evoked Potentials
(drug effects, physiology)
- Female
- Functional Laterality
(drug effects, physiology)
- Humans
- Language Therapy
(methods)
- Male
- Memantine
(pharmacology, therapeutic use)
- Middle Aged
- Photic Stimulation
(methods)
- Reading
- Stroke
(complications, physiopathology, therapy)
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