Analysis of association between sunscreens use and risk of malignant melanoma.

Abstract

BACKGROUND:

Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma.

METHODS:

Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test.

RESULTS:

Twenty-one studies including 7150 malignant melanoma cases about sunscreens use with the risk of malignant melanoma were included in this meta-analysis. The combined relative risk (RR) of malignant melanoma associated with sunscreens use was 1.145 (95% CI=0.912-1.438). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found.

CONCLUSIONS:

Our analysis indicated that sunscreens use is not associated with the risk of malignant melanoma.

• Authors: Fang Xie, Tingting Xie, Qi Song, Shan Xia, Hengjin Li
• Journal: International journal of clinical and experimental medicine (Int J Clin Exp Med) Vol. 8 Issue 2 Pg. 2378-84 ( 2015) ISSN: 1940-5901 [Print] United States
• PMID: 25932176 (Publication Type: Journal Article)