Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.
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| Abstract |
The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 levels were significantly correlated with GS (r = 0.358, P < 0.001) and ES (r = 0.324, P < 0.001) in univariate analysis with all patients. After adjusting for several confounding factors, both GS and ES were associated with FGF-21 in all patients (r = 0.271, P = 0.014; r = 0.217, P = 0.041, respectively). However, FGF-21 lost significant correlation with both GS and ES with type 2 diabetes mellitus in the final model. The patients with type 2 diabetes mellitus and CAD feature had elevated FGF-21 levels. Despite of a limited role in diabetic patients, FGF-21 levels are independently associated with angiographic severity and extent of CAD.
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| Authors | Won Jin Kim, Sang Soo Kim, Han Cheol Lee, Sang Heon Song, Min Jung Bae, Yang Seon Yi, Yun Kyung Jeon, Bo Hyun Kim, Yong Ki Kim, In Joo Kim |
| Journal | Journal of Korean medical science (J Korean Med Sci) Vol. 30 Issue 5 Pg. 586-90 (May 2015) ISSN: 1598-6357 [Electronic] Korea (South) |
| PMID | 25931789 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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