Abstract | BACKGROUND: METHODS: Eligible patients were scheduled to receive bevacizumab combined with etoposide and cisplatin (BEEP) every 3 weeks for a maximum of 6 cycles or until unacceptable toxicity. The primary objective was the central nervous system (CNS)-specific response rate, which was defined as disappearance of cancer cells in the cerebrospinal fluid (CSF) and an improved or stabilized neurologic status. The impact of VEGF inhibition on etoposide penetration into the CSF was analyzed. RESULTS: Eight patients were enrolled. The CNS-specific response rate was 60% in 5 evaluable patients. According to intent-to-treat analysis, the median overall survival of the eight patients was 4.7 months (95% confidence interval, CI, 0.3-9.0) and the neurologic progression-free survival was 4.7 months (95% CI 0-10.5). The most common grade 3/4 adverse events were neutropenia (23.1%), leukopenia (23.1%), and hyponatremia (23.1%). The etoposide concentrations in the CSF were much lower than those in plasma, and bevacizumab did not increase etoposide delivery to the CSF. CONCLUSIONS: TRIAL REGISTRATION: ClinicalTrials.gov identifying number NCT01281696 .
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Authors | Pei-Fang Wu, Ching-Hung Lin, Ching-Hua Kuo, Wei-Wu Chen, Dah-Cherng Yeh, Hsiao-Wei Liao, Shu-Min Huang, Ann-Lii Cheng, Yen-Shen Lu |
Journal | BMC cancer
(BMC Cancer)
Vol. 15
Pg. 299
(Apr 17 2015)
ISSN: 1471-2407 [Electronic] England |
PMID | 25928457
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bevacizumab
- Etoposide
- Cisplatin
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Topics |
- Adult
- Aged
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Bevacizumab
(administration & dosage, cerebrospinal fluid)
- Breast Neoplasms
(cerebrospinal fluid, complications, drug therapy, pathology)
- Cisplatin
(administration & dosage, cerebrospinal fluid)
- Etoposide
(administration & dosage, cerebrospinal fluid)
- Female
- Humans
- Meningeal Carcinomatosis
(cerebrospinal fluid, complications, drug therapy, pathology)
- Mice
- Middle Aged
- Neoplasm Staging
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