46,XY pure gonadal dysgenesis with gonadoblastoma.

Abstract

A case of gonadoblastoma on one side in streak gonads in a phenotypic female with chromosomal 46,XY pattern is described. The histopathological resemblance between gonadoblastoma and sex cord tumor with annular tubules is discussed. The high serum testosterone level, being unrelated to the administration of human chorionic gonadotropin is valuable for the diagnosis of gonadoblastoma in an individual with dysgenetic gonads. Gonadoblastoma is frequently very small in size and is located in ectopic regions, so that laparotomy with biopsy has been stressed. The hormonal supplement for a postgonadectomized girl is also discussed.

• Authors: T Ikarashi, N Sudo, O Arakawa, M Furuya, M Kato, H Hirasawa, M Kato, H Kaneko
• Journal: Nihon Sanka Fujinka Gakkai zasshi (Nihon Sanka Fujinka Gakkai Zasshi) Vol. 41 Issue 11 Pg. 1831-5 (Nov 1989) ISSN: 0300-9165 [Print] Japan
• PMID: 2592807 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chorionic Gonadotropin
• Testosterone

Topics

• Adolescent
• Chorionic Gonadotropin
• Dysgerminoma (blood, complications, pathology)
• Female
• Gonadal Dysgenesis (complications)
• Gonadal Dysgenesis, 46,XY (complications)
• Humans
• Ovarian Neoplasms (blood, complications, pathology)
• Testosterone (blood)