Recommendation to include a textile dye mix in the European baseline series.

Abstract

BACKGROUND:

Disperse dyes are common sensitizers, but are not currently included in the European baseline series.

OBJECTIVES:

To justify the inclusion of a textile dye mix in the European baseline patch test series.

METHODS:

A survey of the reported frequencies of contact allergy to textile dyes and textile dye mixes was performed by searching PubMed (http://www.ncbi.nlm.gov.ludwig.lub.lu.se/pubmed, last accessed 14 December 2014). The results from a multicentre study performed within the European Environmental Contact Dermatitis Research Group (EECDRG) and published in 2014 formed the final basis for the recommendation.

RESULTS:

The EECDRG study performed in Europe and the United States showed that 2.1-6.9% of consecutively tested dermatitis patients reacted to a 6.6% wt/wt textile dye mix consisting of eight disperse dyes. The clinical relevance was ascertained in >30% of the positive cases. A high frequency of simultaneous sensitivity to Disperse Orange 3 (DO 3) and p-phenylenediamine (PPD) was seen. Active sensitization to the mix was not noted.

CONCLUSIONS:

It is recommended to include a 6.6% textile dye mix consisting of eight disperse dyes in the European baseline series, even though one component, DO 3, may be superfluous, owing to its frequent cross-reactivity with PPD. Removal of DO 3 from the mix would need further study.

• Authors: Marléne Isaksson, Kristina Ryberg, An Goossens, Magnus Bruze
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 73 Issue 1 Pg. 15-20 (Jul 2015) ISSN: 1600-0536 [Electronic] England
• PMID: 25925831 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Coloring Agents

Topics

• Coloring Agents (adverse effects)
• Dermatitis, Allergic Contact (diagnosis, epidemiology, etiology)
• Europe (epidemiology)
• Humans
• Patch Tests (methods)
• Textiles (adverse effects)
• United States (epidemiology)