Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo.

Abstract

The aim of this study was to assess the effect of corticosteroids administered intra- and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (≤15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brackmann grading.

• Authors: Alexis Bozorg Grayeli, Evelyne Ferrary, Florence Tubach, Isabelle Bernat, Olivier Deguine, Vincent Darrouzet, Alain Robier, Sandra Zaouche, Christian Dubreuil, Mathieu Marx, Michel Kalamarides, Bernard Fraysse, Olivier Sterkers
• Journal: Audiology & neuro-otology (Audiol Neurootol) Vol. 20 Issue 4 Pg. 213-21 ( 2015) ISSN: 1421-9700 [Electronic] Switzerland
• PMID: 25924803 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• Adrenal Cortex Hormones
• Glucocorticoids
• Methylprednisolone

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Double-Blind Method
• Facial Paralysis (prevention & control)
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Intraoperative Care (methods)
• Male
• Methylprednisolone (therapeutic use)
• Middle Aged
• Neuroma, Acoustic (surgery)
• Postoperative Care (methods)
• Postoperative Complications (prevention & control)
• Young Adult