HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.

Abstract
Retinal ageing results in chronic inflammation, extracellular deposition, including that of amyloid beta (Aβ) and declining visual function. In humans this can progress into age-related macular degeneration (AMD), which is without cure. Therapeutic approaches have focused on systemic immunotherapies without clinical resolution. Here, we show using aged mice that 2-Hydroxypropyl-β-cyclodextrin, a sugar molecule given as eye drops over 3 months results in significant reductions in Aβ by 65% and inflammation by 75% in the aged mouse retina. It also elevates retinal pigment epithelium specific protein 65 (RPE65), a key molecule in the visual cycle, in aged retina. These changes are accompanied by a significant improvement in retinal function measured physiologically. 2-Hydroxypropyl-β-cyclodextrin is as effective in reducing Aβ and inflammation in the complement factor H knockout (Cfh(-/-)) mouse that shows advanced ageing and has been proposed as an AMD model. β-cyclodextrin is economic, safe and may provide an efficient route to reducing the impact of retinal ageing.
AuthorsJaimie Hoh Kam, Aisling Lynch, Rana Begum, Alex Cunea, Glen Jeffery
JournalExperimental eye research (Exp Eye Res) Vol. 135 Pg. 59-66 (Jun 2015) ISSN: 1096-0007 [Electronic] England
PMID25921262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
Chemical References
  • Amyloid beta-Peptides
  • Complement C3
  • Membrane Lipids
  • beta-Cyclodextrins
  • retinoid isomerohydrolase
  • cis-trans-Isomerases
Topics
  • Administration, Topical
  • Aging (physiology)
  • Amyloid beta-Peptides (metabolism)
  • Analysis of Variance
  • Animals
  • Complement C3 (metabolism)
  • Disease Models, Animal
  • Electroretinography (drug effects)
  • Inflammation (drug therapy)
  • Membrane Lipids (metabolism)
  • Mice
  • Mice, Inbred C57BL
  • Retina (drug effects, physiology)
  • beta-Cyclodextrins (administration & dosage, pharmacology)
  • cis-trans-Isomerases (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: