Abstract |
Retinal ageing results in chronic inflammation, extracellular deposition, including that of amyloid beta (Aβ) and declining visual function. In humans this can progress into age-related macular degeneration (AMD), which is without cure. Therapeutic approaches have focused on systemic immunotherapies without clinical resolution. Here, we show using aged mice that 2-Hydroxypropyl-β-cyclodextrin, a sugar molecule given as eye drops over 3 months results in significant reductions in Aβ by 65% and inflammation by 75% in the aged mouse retina. It also elevates retinal pigment epithelium specific protein 65 (RPE65), a key molecule in the visual cycle, in aged retina. These changes are accompanied by a significant improvement in retinal function measured physiologically. 2-Hydroxypropyl-β-cyclodextrin is as effective in reducing Aβ and inflammation in the complement factor H knockout (Cfh(-/-)) mouse that shows advanced ageing and has been proposed as an AMD model. β- cyclodextrin is economic, safe and may provide an efficient route to reducing the impact of retinal ageing.
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Authors | Jaimie Hoh Kam, Aisling Lynch, Rana Begum, Alex Cunea, Glen Jeffery |
Journal | Experimental eye research
(Exp Eye Res)
Vol. 135
Pg. 59-66
(Jun 2015)
ISSN: 1096-0007 [Electronic] England |
PMID | 25921262
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Amyloid beta-Peptides
- Complement C3
- Membrane Lipids
- beta-Cyclodextrins
- retinoid isomerohydrolase
- cis-trans-Isomerases
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Topics |
- Administration, Topical
- Aging
(physiology)
- Amyloid beta-Peptides
(metabolism)
- Analysis of Variance
- Animals
- Complement C3
(metabolism)
- Disease Models, Animal
- Electroretinography
(drug effects)
- Inflammation
(drug therapy)
- Membrane Lipids
(metabolism)
- Mice
- Mice, Inbred C57BL
- Retina
(drug effects, physiology)
- beta-Cyclodextrins
(administration & dosage, pharmacology)
- cis-trans-Isomerases
(metabolism)
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