Single nucleotide polymorphisms in the Gc gene for vitamin D binding protein in common cancers in Thailand.

Abstract

BACKGROUND:

This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) and 3 common cancers (breast, lung and colorectal) in Thai patients.

MATERIALS AND METHODS:

Two hundred and eighty two colorectal, 101 breast and 113 lung cancer patients were recruited from one institute during 2011-2013. The controls were age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels were compared among different genotypes in the 2 SNPs.

RESULTS:

The minor allele frequencies of rs7041 (G) and rs4588 (A) were 0.32 and 0.24, respectively. Under the dominant model, the study found significant associations between minor-allele genotypes of the SNP rs7041 (TG/GG) and lung cancer (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minor- allele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37). When SNP combinations (rs7041-rs4588) were examined, the TT-CA combination had a significant protective association with lung cancer (OR 0.44, 95% CI 0.22-0.85). On evaluation of serum 25(OH)D levels in 205 individuals without cancer (males 144, females 61), the proportion of subjects with low serum vitamin D (< 20 ng/ml) in those harboring CA or AA genotypes of rs4588 (41.7%) was significantly higher than the CC genotype (15.5%, p-value < 0.01).

CONCLUSIONS:

Genetic polymorphisms in Gc were associated with lung and colorectal cancers in Thai patients. Lower serum 25(OH)D in minor variants of rs4588 may explain this association.

• Authors: Wanwisa Maneechay, Teeranut Boonpipattanapong, Samornmas Kanngurn, Puttisak Puttawibul, Sarayut Lucien Geater, Surasak Sangkhathat
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 8 Pg. 3339-44 ( 2015) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25921141 (Publication Type: Journal Article)

Chemical References

• Vitamin D-Binding Protein
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adult
• Aged
• Alleles
• Asian People (genetics)
• Breast Neoplasms (blood, genetics)
• Case-Control Studies
• Colorectal Neoplasms (blood, genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lung Neoplasms (blood, genetics)
• Male
• Middle Aged
• Odds Ratio
• Polymorphism, Single Nucleotide
• Thailand
• Vitamin D (analogs & derivatives, blood)
• Vitamin D-Binding Protein (genetics)