Perioperative administration of Daikenchuto (TJ-100) reduces the postoperative paralytic ileus in patients with pancreaticoduodenectomy.

Abstract

BACKGROUND/AIMS:

No study has reported whether perioperative administration of Daikenchuto (TJ-100) reduced paralytic ileus after pancreaticoduodenectomy (PD).

METHODOLOGY:

Forty-five consecutive patients that were scheduled to undergo PD at Wakayama Medical University Hospital between August 2010 and August 2011 were enrolled in this study including the first cohort (n = 15) as the control group and the subsequent cohort (n = 30) as the TJ-100 group. This trial was registered at UMIN-CTR ID# 000005056.

RESULTS:

Postoperative paralytic ileus occurred more frequently in the control group (73.3% of the control group and 20.0% of the TJ-100 group; p = 0.001). The first passages of flatus significantly improved earlier in the TJ-100 group than in the control group (p = 0.014). A multiple cytokine assay of the drainage and serum showed that IL-9 and IL-10 in the drainage was significantly higher on postoperative day 1 in the TJ-100 group. There were no complications associated with the preoperative administration of TJ-100 before surgery, and no significant differences were observed between the two groups in the incidence of postoperative Gradel-2 diarrhea (CTCAE4.0).

CONCLUSIONS:

Perioperative administration of TJ-100 was feasible and reduced the incidence of paralytic ileus in PD, and further randomized controlled trials should be conducted.

• Authors: Ken-Ichi Okada, Manabu Kawai, Seiko Hirono, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Hiroki Yamaue
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2015 Mar-Apr Vol. 62 Issue 138 Pg. 466-71 ISSN: 0172-6390 [Print] Greece
• PMID: 25916084 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Gastrointestinal Agents
• IL10 protein, human
• IL9 protein, human
• Interleukin-9
• Plant Extracts
• dai-kenchu-to
• Interleukin-10

Topics

• Digestive System Neoplasms (surgery)
• Drug Administration Schedule
• Female
• Gastrointestinal Agents (administration & dosage, adverse effects)
• Hospitals, University
• Humans
• Interleukin-10 (blood)
• Interleukin-9 (blood)
• Intestinal Pseudo-Obstruction (blood, diagnosis, etiology, prevention & control)
• Japan
• Male
• Panax
• Pancreaticoduodenectomy (adverse effects)
• Pilot Projects
• Plant Extracts (administration & dosage, adverse effects)
• Prospective Studies
• Quality of Life
• Surveys and Questionnaires
• Time Factors
• Treatment Outcome
• Zanthoxylum
• Zingiberaceae