Warm autoimmune hemolytic anemia with mimicking anti-e specificity causing intravascular hemolysis in a chronic ITP patient.

Abstract

A 12-year-old male child presented to the emergency room with three days history of cola-colored urine, mild icterus, dyspnea, palpitation and fatigue. He had a history of chronic ITP two years ago and had since been on steroid for maintenance of platelet count. He was subsequently diagnosed as a case of warm autoimmune hemolytic anemia. Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking anti-e specificity. The specificity of autoantibody was further confirmed by adsorption study. The patient was successfully managed by transfusion of Rh(e)-negative red cells,steroid and rituximab therapy. So an autoantibody with mimicking anti-e specificity was identified in this case, which was significant in clinical point of view.

• Authors: Suvro Sankha Datta, Mahua Reddy, Sabita Basu
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 53 Issue 2 Pg. 205-7 (Oct 2015) ISSN: 1473-0502 [Print] England
• PMID: 25913358 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Autoantibodies
• Steroids
• Immunoglobulin E
• Rituximab

Topics

• Anemia, Hemolytic, Autoimmune (blood, therapy)
• Autoantibodies (blood)
• Child
• Chronic Disease
• Erythrocyte Transfusion
• Hemolysis
• Humans
• Immunoglobulin E
• Male
• Purpura, Thrombocytopenic, Idiopathic (blood, therapy)
• Rituximab (administration & dosage)
• Steroids (administration & dosage)