Effect of sulfur dioxide inhalation on the expression of KATP and L-Ca(2+) channels in rat hearts.

Abstract

Epidemiological studies have revealed an association between sulfur dioxide (SO2) exposure and cardiovascular diseases. This study is designed to investigate the SO2 effect on the expression of ATP-sensitive K(+) (KATP) channel and L-type calcium (L-Ca(2+)) channel in rat hearts. The results show that the mRNA and protein levels of the KATP channel subunits Kir6.2 and SUR2A of rat hearts in SO2 groups were higher than those in control group. SO2 at 14mg/m(3) significantly decreased the expression of the L-Ca(2+) channel subunits Cav1.2 and Cav1.3. This suggests that SO2 can activate the KATP channels by up-regulating the expression of Kir6.2 and SUR2A, while it inhibits the L-Ca(2+) channels by down-regulating the expression of Cav1.2 and Cav1.3 in rat hearts. The molecular mechanism of SO2-induced negative inotropic effect might be linked to the expression changes of these subunits, which may contribute to the pathogenesis of SO2-associated cardiovascular diseases.

• Authors: Quanxi Zhang, Yunlong Bai, Zhenhua Yang, Jingjing Tian, Ziqiang Meng
• Journal: Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 39 Issue 3 Pg. 1132-8 (May 2015) ISSN: 1872-7077 [Electronic] Netherlands
• PMID: 25912853 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Calcium Channels, L-Type
• KATP Channels
• Kir6.2 channel
• Potassium Channels, Inwardly Rectifying
• Sulfonylurea Receptors
• Sulfur Dioxide

Topics

• Animals
• Calcium Channels, L-Type (drug effects, genetics, metabolism)
• Down-Regulation
• Gene Expression Regulation, Enzymologic (drug effects)
• Heart (drug effects)
• Inhalation
• KATP Channels (drug effects, genetics, metabolism)
• Male
• Potassium Channels, Inwardly Rectifying (drug effects, genetics, metabolism)
• Rats
• Rats, Wistar
• Sulfonylurea Receptors (drug effects, genetics, metabolism)
• Sulfur Dioxide (toxicity)
• Up-Regulation