Abstract | BACKGROUND: METHODS: We reviewed data from 38 patients with locally advanced cancer of the esophagus or esophagogastric junction who underwent trimodality therapy comprising neoadjuvant CRT with DOC and 5FU followed by esophagectomy between 2003 and 2008. RESULTS:
Esophagitis was the most common toxicity associated with neoadjuvant CRT (grade 3; 26.3%), and hematologic toxicity was mild. Transthoracic esophagectomy and pharyngolaryngoesophagectomy proceeded in 36 (94.7%) and 2 (5.3%) patients, respectively, and 35 (92.1%) underwent R0 resection. Five (13.2%) patients had complete pathologic responses (pCR) of the primary tumor, and 23 (60.5%) had pathologic reductions of over two-thirds of the primary tumor. The T or N status was also down-staged in 26 (68.4%) patients. Overall postoperative morbidity developed in 21 (55.3%) patients, and mortality due to postoperative morbidity was zero. The 5-year recurrence-free and overall survival rates were 39.5% and 44.7%, respectively. CONCLUSIONS: The rates of neoadjuvant CRT toxicity and postoperative complications were acceptable, and the complete resection rate and survival data were favorable. This regimen is promising as neoadjuvant CRT for esophageal cancer and very useful as an alternative regimen for treating patients with esophageal cancer who cannot tolerate cisplatin.
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Authors | Yoichi Hamai, Jun Hihara, Manabu Emi, Yuji Murakami, Masahiro Kenjo, Yasushi Nagata, Morihito Okada |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 99
Issue 6
Pg. 1887-93
(Jun 2015)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 25912745
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Immunosuppressive Agents
- Taxoids
- Docetaxel
- Fluorouracil
|
Topics |
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage)
- Chemoradiotherapy, Adjuvant
- Disease-Free Survival
- Docetaxel
- Drug Therapy, Combination
- Esophageal Neoplasms
(diagnosis, mortality, therapy)
- Esophagectomy
- Female
- Fluorouracil
(administration & dosage)
- Follow-Up Studies
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Japan
(epidemiology)
- Male
- Middle Aged
- Neoplasm Staging
- Postoperative Care
(methods)
- Retrospective Studies
- Survival Rate
(trends)
- Taxoids
(administration & dosage)
- Treatment Outcome
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