Abstract | BACKGROUND: OBJECTIVE: To investigate sFLT1, PGF and ADMA in the first trimester of pregnancy as predictors of preeclampsia. METHODS: In this prospective nested case-control study, 740 pregnant women enrolled at 12-16 weeks of gestation and followed up until 6 weeks after delivery at the Shanghai First Maternity and Infant Health Hospital of Tongji University between January 2010 and December 2012. Forty-four women developed preeclampsia. Urinary proteins were measured using 24-hour collection or dipsticks. sFLT1, PGF and ADMA were measured by ELISA in the first trimester. Pulsatility index (PI) was measured by Doppler ultrasound in the second trimester. RESULTS: First-trimester serum sFLT1 and ADMA levels of women who developed preeclampsia were significantly higher compared with women with normal pregnancies (sFLT1: 0.321 ± 0.023 vs. 0.308 ± 0.019 ng/ml, P = 0.001; ADMA: 0.86 ± 0.16 vs. 0.68 ± 0.20 μM, P < 0.001). First-trimester serum PGF levels of women who developed preeclampsia were significantly lower than in women with normal pregnancies (115.72 ± 32.55 vs. 217.30 ± 74.48 pg/ml, P < 0.001). Multiple logistic regression and receiver-operating characteristic curves identified first-trimester PGF and ADMA to be sensitive and selective predictors of preeclampsia (area under the curve [AUC]: 0.902), as well as second-trimester uterine artery pulse index (AUC: 0.836). CONCLUSION: In the first trimester, maternal serum sFLT1, PGF and ADMA levels, as well as second-trimester uterine artery PI, could predict preeclampsia.
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Authors | Zheng Bian, Chenzi Shixia, Tao Duan |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 4
Pg. e0124684
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25906026
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- PGF protein, human
- Pregnancy Proteins
- Placenta Growth Factor
- N,N-dimethylarginine
- Arginine
- FLT1 protein, human
- Vascular Endothelial Growth Factor Receptor-1
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Topics |
- Adult
- Area Under Curve
- Arginine
(analogs & derivatives, blood)
- Blood Pressure
(physiology)
- Case-Control Studies
- Demography
- Female
- Follow-Up Studies
- Humans
- Logistic Models
- Placenta Growth Factor
- Pre-Eclampsia
(blood, diagnosis, diagnostic imaging)
- Pregnancy
- Pregnancy Proteins
(blood)
- Pregnancy Trimester, First
- Pregnancy Trimester, Second
- Prospective Studies
- ROC Curve
- Ultrasonography
- Uterine Artery
(physiology)
- Vascular Endothelial Growth Factor Receptor-1
(blood)
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