Acquired factor V inhibitor in a patient receiving venous-venous extracorporeal membrane oxygenation for Legionella pneumonia.

Abstract

We report a rare complication of factor V deficiency in a patient having Legionella pneumonia. This patient also had other complications like severe acute respiratory distress syndrome, acute kidney injury, and septic shock that required venous-venous extracorporeal membrane oxygenation support. This is the first reported case of acquired factor V deficiency in a patient receiving extracorporeal membrane oxygenation for Legionella pneumonia. With the combined use of intravenous immunoglobulin, rituximab and plasma exchange, we achieved rapid clearance of the factor V inhibitor within 1 week so as to allow safe decannulation of extracorporeal membrane oxygenation.

• Authors: Anne K H Leung, George W Y Ng, K C Sin, S Y Au, K Y Lai, K L Lee, K I Law
• Journal: Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine (Hong Kong Med J) Vol. 21 Issue 2 Pg. 175-8 (Apr 2015) ISSN: 1024-2708 [Print] China
• PMID: 25904567 (Publication Type: Journal Article)