Intracameral cefuroxime and the incidence of post-cataract endophthalmitis: an Israeli experience.

Abstract

PURPOSE:

The European Society of Cataract & Refractive Surgeons (ESCRS) study reported a decrease in endophthalmitis rates from 0.34 % to 0.08 % with the use of intracameral cefuroxime. The purpose of this study was to compare the endophthalmitis rates before and after the introduction of intracameral cefuroxime (ICC) routinely at the end of cataract surgery.

METHODS:

A retrospective consecutive cohort study. We compared the rates of endophthalmitis between the years 2000-2006, and the years 2007-2014, after the pivotal publication of the ESCRS. Data collected included age, gender, culture results, initial and final visual acuity, and complications. Only patients that presented with endophthalmitis following cataract surgery performed at the two centers were included.

RESULTS:

Twenty-two cases of endophthalmitis occurred between the years 2000 and 2006, out of 26,663 cataract operations performed at the two centers, a rate of 0.083 %. Ten cases occurred between the years 2007 and 2014 out of 29,431 cataract operations, a rate of 0.034 %. The difference was statistically significant (p = 0.03) CONCLUSIONS: The introduction of prophylactic use of intracameral cefuroxime was associated with a significant reduction in post-operative endophthalmitis rates in our centers. We strongly recommend adoption of this routine by for all cataract operations except when contraindicated.

• Authors: Gabriel Katz, Sharon Blum, Omer Leeva, Ruth Axer-Siegel, Joseph Moisseiev, Gili Tesler, Rita Ehrlich
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 253 Issue 10 Pg. 1729-33 (Oct 2015) ISSN: 1435-702X [Electronic] Germany
• PMID: 25904294 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Anti-Bacterial Agents
• Cefuroxime

Topics

• Adult
• Aged
• Aged, 80 and over
• Anterior Chamber (drug effects)
• Anti-Bacterial Agents (therapeutic use)
• Bacteria (isolation & purification)
• Cataract Extraction (adverse effects)
• Cefuroxime (therapeutic use)
• Endophthalmitis (epidemiology, microbiology, prevention & control)
• Eye Infections, Bacterial (epidemiology, microbiology, prevention & control)
• Female
• Humans
• Incidence
• Israel (epidemiology)
• Male
• Middle Aged
• Postoperative Complications
• Retrospective Studies