Risk of Malnutrition, Trace Metal, and Vitamin Deficiency Post Roux-en-Y Gastric Bypass--a Prospective Study of 20 Patients with BMI < 35 kg/m².

Abstract

BACKGROUND:

Due to its reliable effects on type 2 diabetes mellitus (T2DM) remission, Roux-en-Y gastric bypass (RYGB) has recently been investigated as a treatment option for nonseverely obese patients with T2DM (body mass index (BMI) <35 kg/m(2)). The purpose of this study was to investigate whether RGYB induces malnutrition of macro- and micronutrients within 24 months in these patients.

METHODS:

A prospective cohort of 20 patients with longstanding, insulin-dependent T2DM and a BMI of 25-35 kg/m(2) were treated with RYGB. The patients were supplemented with over-the-counter, multivitamin, and micronutrient supplements. Serum concentrations of albumin, vitamins, and trace elements, hemoglobin, and bone density were measured preoperatively and over a 24-month period (DRKS00004605).

RESULTS:

RYGB did not result in underweight or protein malnutrition. No new onset of deficiencies of water- or fat-soluble vitamins developed over the study period. However, serum selenium, zinc, and ferritin decreased significantly (selenium, 1.17 ± 0.13 to 0.89 ± 0.11 μmol/l, p = 0.018; zinc, 13.9 ± 0.5 to 10.8 ± 0.5 μmol/l, p = 0.012; ferritin, 171.7 ± 26.9 to 31.8 ± 11.2 μg/l, p = 0.018). Hemoglobin remained stable. Vitamin D (13.7 ± 1.8 to 19.1 ± 1.1 ng/ml, p = 0.017) and osteocalcin (15.3 ± 1.7 to 25.4 ± 2.7 ng/ml, p = 0.025) rose significantly, whereas the parathyroid hormone remained stable. Despite increased bone formation, bone density decreased (T score hip, 0.15 ± 0.25 to -0.71 ± 0.34, p = 0.005) resulting in a significant increase in osteopenia rates (18 to 50 %, p = 0.046).

CONCLUSIONS:

This is the first prospective cohort to investigate malnutrition after RYGB in nonseverely obese patients. These patients are at risk of developing iron, selenium, and zinc deficiencies within 24 months, as well as osteopenia despite an increase in bone formation.

• Authors: Adrian T Billeter, Pascal Probst, Lars Fischer, Jonas Senft, Hannes G Kenngott, Thilo Schulte, Gabriella Clemens, Ulrike Zech, Markus W Büchler, Peter P Nawroth, Beat P Müller-Stich
• Journal: Obesity surgery (Obes Surg) Vol. 25 Issue 11 Pg. 2125-34 (Nov 2015) ISSN: 1708-0428 [Electronic] United States
• PMID: 25904235 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Trace Elements
• Ferritins
• Selenium
• Zinc

Topics

• Adolescent
• Adult
• Aged
• Avitaminosis (blood, epidemiology)
• Body Mass Index
• Bone Diseases, Metabolic (epidemiology)
• Diabetes Mellitus, Type 2 (blood, complications, surgery)
• Female
• Ferritins (blood)
• Gastric Bypass (adverse effects, statistics & numerical data)
• Humans
• Iron Deficiencies
• Malabsorption Syndromes (blood, epidemiology, etiology)
• Male
• Malnutrition (blood, epidemiology)
• Middle Aged
• Obesity (blood, complications, surgery)
• Postoperative Complications (blood, epidemiology)
• Risk Factors
• Selenium (deficiency)
• Trace Elements (blood)
• Young Adult
• Zinc (blood, deficiency)