Abstract | BACKGROUND: METHODS: Ninety-eight patients undergoing elective renal transplantation were randomised into two groups: nefopam or control groups. The former received nefopam (160 mg in 200 ml at a rate of 4 ml/h) whereas the latter received normal saline during the first 48 h after reperfusion of grafted kidney. Pain intensity scores, cumulative dose of fentanyl, and the incidence of adverse events were assessed at 1, 6, 12, 24, and 48 h post-operatively. Serum creatinine and estimated glomerular filtration rate were evaluated on post-operative days 1, 2, 4, and 7. RESULTS: The cumulative fentanyl consumption during the first 48 h after operation was 19% less in the nefopam group than that in the control group (1005 ± 344 μg vs. 1246 ± 486 μg, mean ± SD; P = 0.006). Pain intensity scores at rest and on coughing were significantly lower in the nefopam group throughout the first 12 and 48 h after operation, respectively. Adverse events and early graft function were comparable between the groups, except a significantly lower incidence of drowsiness observed in the nefopam group (4% vs. 21%, P = 0.027). CONCLUSION:
|
Authors | S Y Kim, K H Huh, Y H Roh, Y J Oh, J Park, Y S Choi |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 59
Issue 8
Pg. 1068-75
(Sep 2015)
ISSN: 1399-6576 [Electronic] England |
PMID | 25903742
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | © 2015 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. |
Chemical References |
- Analgesics, Non-Narcotic
- Nefopam
|
Topics |
- Administration, Intravenous
- Adult
- Analgesia, Patient-Controlled
(methods)
- Analgesics, Non-Narcotic
(administration & dosage, therapeutic use)
- Female
- Humans
- Kidney Transplantation
- Male
- Middle Aged
- Nefopam
(administration & dosage, therapeutic use)
- Pain, Postoperative
(drug therapy)
- Treatment Outcome
- Young Adult
|