HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Use of a plant-based polysaccharide hemostat for the treatment of sternal bleeding after median sternotomy.

AbstractBACKGROUND:
In cardiac surgery profuse or persistent sternal bleeding after sternotomy is routinely controlled with bone wax. However, bone wax should be avoided, especially in high-risk patients for nonunion of the sternum and infections. Purpose of this study was to evaluate an alternative technique to control bleeding after medium sternotomy using a plant based absorbable polysaccharide hemostat.
METHODS:
A consecutive series of 38 patients requiring median sternotomy for coronary artery bypass surgery (21 OPCAB, 17 CABG) had sternal bleeding control with the polysaccharide hemostat, STARSIL® HEMOSTAT. This hemostat is a hydrophilic powder, which achieves hemostasis after topical application at the surgical wound site. Initially it dehydrates blood rapidly, thus accelerating aggregation of platelets and blood solids. Thereafter, it forms a gelled adhesive matrix, which serves as a mechanical barrier against further bleeding. The polysaccharide is completely resorbed within 48 to 72 hours.
RESULTS:
Satisfactory control of sternal bleeding was observed in 37 patients (97%). No product-related complications were observed or any other major adverse events in an observation period of 3 months.
CONCLUSION:
Polysaccharide hemostats appear to be safe and effective for bleeding control of the sternum.
AuthorsChristoph Schmitz, Ralf Sodian
JournalJournal of cardiothoracic surgery (J Cardiothorac Surg) Vol. 10 Pg. 59 ( 2015) ISSN: 1749-8090 [Electronic] England
PMID25902769 (Publication Type: Clinical Study, Journal Article)
Chemical References
  • Hemostatics
  • Phytochemicals
  • Polysaccharides
Topics
  • Aged
  • Aged, 80 and over
  • Coronary Artery Bypass (methods)
  • Female
  • Hemorrhage (drug therapy)
  • Hemostasis, Surgical (methods)
  • Hemostatics (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Phytochemicals (therapeutic use)
  • Polysaccharides (therapeutic use)
  • Sternotomy (methods)
  • Sternum (surgery)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: