Abstract | UNLABELLED: Comparisons of collagenase to other methods of debridement, including wet to dry dressings, have been reported in the literature; however, studies comparing collagenase to hydrogel have not been reported. OBJECTIVE: METHODS: Randomization occurred after obtaining informed consent to avoid selection bias. Subjects received daily dressing changes with either hydrogel or collagenase followed by a standard semi- occlusive dressing to evaluate time to debridement up to Day 42. Investigators, who were blinded to randomization, evaluated weekly wound photographs for necrotic tissue debridement and wound healing parameters using a digital planimetry software package. Nonviable tissue was not cross-hatched in either group. RESULTS: Twenty-seven nursing home residents were enrolled over a period of 1 year. According to a Student's t test, there were no significant differences between groups for age, gender, age of wound, or percentage of nonviable tissue at the time of enrollment (P = .03). Using a Pearson Chi square analysis, the collagenase group was found to have statistical (P = .003) significance in achieving full debridement by Day 42. CONCLUSION: This study showed statistical significance in favor of collagenase when used to debride nonviable tissue in pressure ulcers. Despite recommendations to cross-hatch eschar, statistical significance was still achieved when wounds were not cross-hatched, indicating clinical utility in settings without clinician availability for the cross-hatching procedure.
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Authors | Catherine T Milne, Armann O Ciccarelli, Mandie Lassy |
Journal | Wounds : a compendium of clinical research and practice
(Wounds)
Vol. 22
Issue 11
Pg. 270-4
(Nov 2010)
ISSN: 1044-7946 [Print] United States |
PMID | 25901516
(Publication Type: Journal Article)
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