Abstract | BACKGROUND: Cellular channels composed of connexin 43 are known to act as key players in the life cycle of the skin and consequently to underlie skin repair. OBJECTIVE: This study was specifically set up to investigate the suite of molecular mechanisms driven by connexin 43-based channels on wound healing. METHODS: To this end, a battery of parameters, including re-epithelialization, neovascularization, collagen deposition and extracellular matrix remodeling, was monitored over time during experimentally induced skin repair in heterozygous connexin 43 knockout mice. RESULTS: It was found that connexin 43 deficiency accelerates re-epithelialization and wound closure, increases proliferation and activation of dermal fibroblasts, and enhances the expression of extracellular matrix remodeling mediators. CONCLUSION: These data substantiate the notion that connexin 43 may represent an interesting therapeutic target in dermal wound healing.
|
Authors | Bruno Cogliati, Mathieu Vinken, Tereza C Silva, Cintia M M Araújo, Thiago P A Aloia, Lucas M Chaible, Cláudia M C Mori, Maria L Z Dagli |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 79
Issue 1
Pg. 50-56
(Jul 2015)
ISSN: 1873-569X [Electronic] Netherlands |
PMID | 25900674
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
|
Topics |
- Animals
- Cell Proliferation
- Collagen
(metabolism)
- Connexin 43
(deficiency, genetics)
- Extracellular Matrix
(metabolism)
- Fibroblasts
(physiology)
- Heterozygote
- Male
- Mice
- Mice, Knockout
- Neovascularization, Physiologic
- Re-Epithelialization
(physiology)
|