TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 gene polymorphisms as possible risk factor for rheumatoid arthritis: relation to activity and severity.

Abstract

This study was aimed to evaluate the impact of both TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 polymorphisms on susceptibility to rheumatoid arthritis (RA) in a cohort of Egyptian population and to evaluate for the first time their relation to activity, severity, disease-related disability and erosion. TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 gene polymorphisms were typed by RFLP for 128 patients with RA and 125 healthy controls. The A allele, A-containing genotypes (GA and AA) of the TIM-4 and GA haplotype were present with significant higher frequency in patients with RA than healthy controls (Pc  < 0.001). These findings suggest that the A allele, A-containing genotypes (GA and AA) and GA haplotype may be a susceptibility risk factor for RA [OR = 5.83 (3.6-9.4), OR = 9.41 (5.0-17.6) and OR = 4.21 (1.07-19.2), respectively]. No associations were found between TIM genotypes and disease activity, severity or presence of erosion. However, the RA patients with GA genotype of TIM-4 have higher grade of rheumatoid factor (RF) positivity (P = 0.018), and have worse disease-related disability (P = 0.007) and worse pain (0.025). TIM-4 rs7700944 and not TIM-1 rs41297579 G>A (-1454) is associated with RA in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian. Both SNPs have no effect on disease activity, severity or erosion. However, TIM-4 GA genotype is associated with higher grade of RF positivity and worse disease-related disability and pain.

• Authors: Y M Mosaad, S R El-Bassiony, A E El-Ghaweet, M M Elhindawy, B S El-Deek, W A Sultan
• Journal: International journal of immunogenetics (Int J Immunogenet) Vol. 42 Issue 4 Pg. 254-64 (Aug 2015) ISSN: 1744-313X [Electronic] England
• PMID: 25899833 (Publication Type: Journal Article)
• Copyright: © 2015 John Wiley & Sons Ltd.

Chemical References

• HAVCR1 protein, human
• Hepatitis A Virus Cellular Receptor 1
• Membrane Glycoproteins
• Membrane Proteins
• Receptors, Virus
• TIMD4 protein, human

Topics

• Adult
• Alleles
• Arthritis, Rheumatoid (genetics, pathology)
• Egypt
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Hepatitis A Virus Cellular Receptor 1
• Humans
• Male
• Membrane Glycoproteins (genetics)
• Membrane Proteins (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide
• Receptors, Virus (genetics)
• Risk Factors