Abstract |
Quercetin (Que) is one of main compounds in Lysimachia christinae Hance (Christina loosestrife), and has both medicinal and nutritional value. Glycosides from Tripterygium wilfordii Hook.f. (léi gōng téng [the thunder duke vine]; TG) have diverse and broad bioactivities but with a high incidence of liver injury. Our previous study reported on the hepatoprotective properties of an ethanol extract from L. christinae against TG-induced liver injury in mice. This research is designed to observe, for the first time, the possible protective properties of the compound Que against TG-induced liver injury, and the underlying mechanisms that are involved in oxidative stress and anti- inflammation. The results indicated that TG caused excessive elevation in serum levels of alanine/ aspartate transaminase (ALT/AST), alkaline phosphatase (ALP), gamma glutamyl transferase (γ-GT), and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α), as well as hepatic lipid peroxidation (all P < 0.01). On the other hand, following TG exposure, we observed significantly reduced levels of biomarkers, including hepatic glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPx), and the anti-inflammatory cytokine interleukin (IL)-10, as well as the enzyme activity and mRNA expression of copper- and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) (all P < 0.01). Nevertheless, all of these alterations were reversed by the pre-administration of Que or the drug bifendate (positive control) for 7 consecutive days. Therefore, this study suggests that Que ameliorates TG-induced acute liver injury, probably through its ability to reduce oxidative stress and its anti-inflammatory properties.
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Authors | Junming Wang, Mingsan Miao, Yueyue Zhang, Ruixin Liu, Xaobing Li, Ying Cui, Lingbo Qu |
Journal | Canadian journal of physiology and pharmacology
(Can J Physiol Pharmacol)
Vol. 93
Issue 6
Pg. 427-33
(Jun 2015)
ISSN: 1205-7541 [Electronic] Canada |
PMID | 25894526
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Biomarkers
- Glycosides
- Protective Agents
- Quercetin
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Biomarkers
(metabolism)
- Chemical and Drug Induced Liver Injury
(drug therapy, metabolism)
- Glycosides
(adverse effects)
- Inflammation
(drug therapy, metabolism)
- Liver
(drug effects, metabolism)
- Male
- Mice
- Oxidative Stress
(drug effects)
- Protective Agents
(pharmacology)
- Quercetin
(pharmacology)
- Serum
(metabolism)
- Tripterygium
(adverse effects)
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