HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Endovascular thrombolysis to salvage central venous access in children with catheter-associated upper extremity deep vein thrombosis: technique and initial results.

Abstract
Nine patients (average age 8.3 years, range 20 days to 17 years; average weight 31 kg, range 2.7-79 kg) with catheter-associated UE-DVT underwent upper extremity venous thrombolysis with the goal of access salvage. Catheter directed therapy with alteplase (tPA), balloon angioplasty, and mechanical thrombectomy was used in all cases. The mean total dose of TPA was 15 mg (range 1-40 mg). Venous access was ultimately preserved in all patients. No stents or superior vena cava filters were used. There was one episode of symptomatic clinically suspected pulmonary embolism managed by systemic tPA and heparin without long term sequaele. Mean imaging and clinical follow-up was 351 ± 208 and 613 ± 498 days respectively. Endovenous thrombolysis for catheter-associated upper-extremity DVT in children may be safe and effective and could be considered particularly in patients in whom long-term venous access is needed.
AuthorsMatthew P Lungren, Thomas J Ward, Manish N Patel, John M Racadio, Kamlesh Kukreja
JournalJournal of thrombosis and thrombolysis (J Thromb Thrombolysis) Vol. 40 Issue 3 Pg. 274-9 (Oct 2015) ISSN: 1573-742X [Electronic] Netherlands
PMID25894473 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Tissue Plasminogen Activator
Topics
  • Adolescent
  • Central Venous Catheters (adverse effects)
  • Child
  • Child, Preschool
  • Endovascular Procedures (methods)
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Mechanical Thrombolysis
  • Thrombolytic Therapy (methods)
  • Tissue Plasminogen Activator (administration & dosage)
  • Venous Thrombosis (etiology, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: