Abstract | OBJECTIVE: STUDY DESIGN: A single centre double blind randomized controlled trial was performed at the obstetrical tertiary high care unit of the University Medical Centre in Rotterdam, the Netherlands. Women with severe hypertension in pregnancy (diastolic blood pressure (DBP)≥110mmHg), and significant proteinuria (≥300mg/24h), and gestational age≤32 weeks were eligible for the study. All patients ( n=30) received two infusions (double dummy technique): one contained the active ingredient ( ketanserin or dihydralazine), the other was used for placebo. Nicardipine was used as rescue medication. The main outcome measures were persistent severe hypertension (DBP>100mmHg>120min) despite maximum dosage of study medication and prolongation of pregnancy. RESULTS:
Dihydralazine was significantly more effective in lowering blood pressure than ketanserin. No significant difference in prolongation of pregnancy was seen between the two groups. After 30 inclusions, the study was stopped because of the high rate of persistent hypertension using ketanserin and the high rate of maternal side effects using dihydralazine and the apparent succesful use of the rescue drug nicardipine. CONCLUSIONS:
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Authors | Sebastiaan W Nij Bijvank, Willy Visser, Johannes J Duvekot, Eric A Steegers, Mireille A Edens, Danielle W Roofthooft, Arnold G Vulto, Lidwien M Hanff |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 189
Pg. 106-11
(Jun 2015)
ISSN: 1872-7654 [Electronic] Ireland |
PMID | 25892082
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antihypertensive Agents
- Ketanserin
- Nicardipine
- Dihydralazine
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Topics |
- Adult
- Antihypertensive Agents
(therapeutic use)
- Dihydralazine
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Gestational Age
- Hospitals, University
- Humans
- Hypertension
(complications, drug therapy)
- Ketanserin
(adverse effects, therapeutic use)
- Netherlands
- Nicardipine
(therapeutic use)
- Pre-Eclampsia
(physiopathology)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(drug therapy)
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