Effect of the -148C/T, 448G/A, and -854G/A Polymorphisms of the β-Fibrinogen Gene on the Risk of Ischemic Stroke in Chinese Population.

Abstract

BACKGROUND:

Several investigations have been performed to examine the influence of the β-fibrinogen (FGβ) gene polymorphisms on the risk of ischemic stroke, but the results of these studies are controversial. Our study aimed at investigating whether the FGβ gene (-148 C/T, 448 G/A, and -854 G/A) polymorphisms were associated with susceptibility to ischemic stroke by conducting meta-analysis.

METHODS:

Relevant studies were identified from 4 Chinese databases, PUBMED and EMBASE before May 30, 2014. The strength of association was evaluated by the odds ratio with 95% confidence interval. Inconsistency index and the Cochran's Q statistic were used to check heterogeneity. Publication bias was tested using funnel plots and Egger's regression test.

RESULTS:

Thirty-two independent studies with 4311 cases and 4124 controls were included. Significant association between -148 C/T polymorphism and the risk of ischemic stroke was found in overall analysis and middle-age, but not in young adults and elderly people. Similarly, association was also observed for -854 G/A polymorphism, especially in cerebral arterial main trunk infarction (MCI) and cerebral penetrating arterial infarction (PCI). However, no significance was found between 448 G/A polymorphism and ischemic stroke in Chinese people; likewise, no evidence of a significant association was observed when stratified according to the subtype of ischemic stroke (MCI and PCI).

CONCLUSIONS:

These results suggest that -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke.

• Authors: Guangliang Wu, Haiyan Cai, Haobin Cai, Zhao Chen, Lei Tan, Huitao Qi, Yefeng Cai
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 24 Issue 7 Pg. 1577-90 (Jul 2015) ISSN: 1532-8511 [Electronic] United States
• PMID: 25890854 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• FGB protein, human
• Fibrinogen

Topics

• Asian People (genetics)
• Brain Ischemia (diagnosis, ethnology, genetics)
• Case-Control Studies
• China (epidemiology)
• Fibrinogen (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Odds Ratio
• Phenotype
• Polymorphism, Genetic
• Risk Factors
• Stroke (diagnosis, ethnology, genetics)