Emerging EPO and EPO receptor regulators and signal transducers.

Abstract

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), rat sarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/MEK/ERK), and phosphatidylinositol 3-kinase (PI3K) pathways. Contemporary genetic, bioinformatic, and proteomic approaches continue to uncover new clinically relevant modulators of EPO and EPOR expression, and EPO's biological effects. This Spotlight review highlights such factors and their emerging roles during erythropoiesis and anemia.

• Authors: David Kuhrt, Don M Wojchowski
• Journal: Blood (Blood) Vol. 125 Issue 23 Pg. 3536-41 (Jun 04 2015) ISSN: 1528-0020 [Electronic] United States
• PMID: 25887776 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: © 2015 by The American Society of Hematology.

Chemical References

• EPO protein, human
• Receptors, Erythropoietin
• STAT5 Transcription Factor
• Erythropoietin
• Phosphatidylinositol 3-Kinases
• JAK2 protein, human
• Janus Kinase 2
• Extracellular Signal-Regulated MAP Kinases
• ras Proteins

Topics

• Anemia (genetics, metabolism)
• Animals
• Erythroid Precursor Cells (cytology, metabolism)
• Erythropoiesis (physiology)
• Erythropoietin (biosynthesis, genetics)
• Extracellular Signal-Regulated MAP Kinases (genetics, metabolism)
• Gene Expression Regulation (physiology)
• Humans
• Janus Kinase 2 (genetics, metabolism)
• MAP Kinase Signaling System (physiology)
• Phosphatidylinositol 3-Kinases (genetics, metabolism)
• Rats
• Receptors, Erythropoietin (biosynthesis, genetics)
• STAT5 Transcription Factor (genetics, metabolism)
• ras Proteins (genetics, metabolism)