Abstract | BACKGROUNDS:
Yin-Chen-Hao-Tang (YCHT), a commonly used as a traditional chinese medicine for liver disease. Several studies indicated that YCHT may improving hepatic triglyceride metabolism and anti-apoptotic response as well as decreasing oxidative stress .However, little is known about the role of YCHT in chlorpromazine (CPZ) -induced chlolestatic liver injury. Therefore, we aimed to facilitate the understanding of the pathogenesis of cholestatic liver injury and evaluate the effect of Yin-Chen-Hao-Tang (YCHT) on chlorpromazine (CPZ)-induced cholestatic liver injury in rats based on the change of bile acids (BAs) and free fatty acids (FFAs) alone with the biochemical indicators and histological examination. METHODS: RESULTS: Obtained data showed that YCHT attenuated the effect of CPZ-induced cholestatic liver injury, which was manifested by the serum biochemical parameters and histopathology of the liver tissue. YCHT regulated the lipid levels as indicated by the reversed serum levels of TC, TG, and LDL-C. YCHT also regulated the disorder of BA and FFA metabolism by CPZ induction. CONCLUSIONS: Results indicated that YCHT exerted a protective effect on CPZ-induced cholestasis liver injury. The variance of BA and FFA concentrations can be used to evaluate the cholestatic liver injury caused by CPZ and the hepatoprotective effect of YCHT.
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Authors | Qiaoling Yang, Fan Yang, Xiaowen Tang, Lili Ding, Ying Xu, Yinhua Xiong, Zhengtao Wang, Li Yang |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 15
Pg. 122
(Apr 16 2015)
ISSN: 1472-6882 [Electronic] England |
PMID | 25887351
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bile Acids and Salts
- Drugs, Chinese Herbal
- Fatty Acids, Nonesterified
- yin-chen-hao-tang
- Chlorpromazine
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Topics |
- Animals
- Artemisia
- Bile Acids and Salts
(metabolism)
- Chemical and Drug Induced Liver Injury
(metabolism, prevention & control)
- Chlorpromazine
(adverse effects)
- Cholestasis
(chemically induced, metabolism, prevention & control)
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Fatty Acids, Nonesterified
(metabolism)
- Gardenia
- Liver
(drug effects, metabolism, pathology)
- Male
- Mass Spectrometry
- Medicine, Chinese Traditional
- Oxidative Stress
(drug effects)
- Phytotherapy
- Rats
- Rats, Wistar
- Rheum
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